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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 265-162-9 | CAS number: 64742-59-2 A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C13 through C50 and boiling in the range of approximately 230°C to 600°C (446°F to 1112°F). This stream is likely to contain 5 wt. % or more of 4- to 6- membered condensed ring aromatic hydrocarbons.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Information is available from several GLP-compliant studies that have investigated the sensitisation potential of Heavy Fuel Oil Components in the guinea pig using a closed patch technique (Buehler method).
Skin sensitising potential was investigated in a key study in guinea pigs using the closed patch test procedure (API, 1980b). Ten adult male albino guinea pigs were each treated with 0.5 mL of the test material, three times per week for three weeks. The patches were left in place for 6 hours before removal. Two weeks after final application, they were challenged with 0.5 mL of test material. Scores were taken at 24 hours according to the Draize scale. A naive control group of 10 animals and a positive control group of 10 animals were also included. The naive control group was treated with test substance in the challenge phase only. The positive control group was treated with a 0.05% (w/v) dilution of dinitrochlorobenzene in both the sensitizing and challenge phases.
A statistically significant difference between sensitizing and challenge treatments for erythema and oedema was noted among the test animals, but the challenge scores were less than the sensitizing average, indicating that the test substance was non-sensitizing. Based on results of the dermal challenge procedure, the test material was not considered to be a skin sensitiser.
Data are also available from multiple supporting studies (ARCO, 1992v-aa; 1990h,i; 1989j-l; 1988b; 1986h,i, and API, 1982a; 1980a,c,d) conducted in guinea pigs. Results obtained from these studies indicate no obvious potential for the induction or elicitation of dermal sensitisation, however skin irritation was apparent in a number of instances. A satisfactory response was obtained for the negative- and positive control groups.
The results indicate that Heavy Fuel Oil Components are not dermal sensitisers.
Migrated from Short description of key information:
Heavy Fuel Oil Components are not dermal sensitisers.
Justification for selection of skin sensitisation endpoint:
One of 18 available studies.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Migrated from Short description of key information:
This endpoint is not a REACH requirement and no data are available for this endpoint but these substances are not expected to cause respiratory sensitisation.
Justification for classification or non-classification
Results from several GLP-compliant investigations using an induction methodology that met or exceeded the guideline requirements for skin sensitisation testing indicate that Heavy Fuel Oil Components are not dermal sensitisers in the guinea pig. This is consistent with knowledge of the chemistry present, which also indicates they are unlikely to cause respiratory sensitisation. No classification is required under the
EU CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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