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EC number: 500-058-1 | CAS number: 27252-75-1 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 Feb - 08 Mar 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- April 2004
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Samples were taken initial from the test preparation and from pooled replicates after 48 h.
- Sample storage conditions before analysis: no - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
A nominal amount of test item (100 mg) was dissolved in test water and the volume adjusted to 1 liter to give the 100 mg/L test concentration from which a series of dilutions was made to give further test concentrations of 56, 32, 18 and 10 mg/L. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: in-house labroatory breeding
- Age: less than 24 hours
- Feeding during test: no
CULTURE
- Culture conditions: Same as in test
- Type and amount of food: algal suspension (Pseudokirchneriella subcapitata) and GM300 fish food suspension.
- Feeding frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 - 21 °C
- pH:
- control: 7.7 - 8.1
test concentrations: 7.9 - 8.4 - Dissolved oxygen:
- 8.4 - 9.5 mg/L
- Nominal and measured concentrations:
- Nominal test substance concentrations: 10, 18, 32, 56 and 100 mg/L.
Measured test concentrations (initial): 9.89, 15.6, 30.5, 55.5, and 96.2 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass vessels (50 mL nominal volume)
- Type (delete if not applicable): test vessels were covered
- Fill volume: 100 mL
- Aeration: none
- No. of organisms per vessel:5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water (Elendt M7 medium)
- Culture medium different from test medium: no
- Intervals of water quality measurement: daily
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16:8 day/night
- Light intensity: between 200 and 1200 Lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mobility after 24 and 48 hours
RANGE-FINDING STUDY
- Test concentrations: 0.1, 1.0, 10 and 100 mg/L
- Results used to determine the conditions for the definitive study: 100% immobilisation at 100 mg/L
Sub lethal effects of exposure were observed. Trapping at the surface was observed in one control Daphnia and one Daphnia at the test concentration of 10 mg/L was pale. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 40 mg/L
- 95% CI:
- >= 35 - <= 46
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 15.6 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: After 24 h: reduced mobility and pale at 56 mg/L. After 48 h: reduced mobility and pale at 32 and 56 mg/L.
- Mortality of control: no
- Other adverse effects control: Trapping at the surface was observed in one control Daphnia. - Results with reference substance (positive control):
- EC50(48 h): 0.80 mg/L
The positive control was conducted between 25 September 2018 and 27 September 2018. - Reported statistics and error estimates:
- EC50 values: Probit analysis using Linear Maximum Likelihood regression.
LOEC and NOEC values: Calculated using the ToxRat Professional computer software package (TOXRAT). - Validity criteria fulfilled:
- yes
- Remarks:
- For further details please refer to table 3 in “Any other information on results incl. tables”.
Reference
Description of key information
EC50 (48 h): 40 mg/L (nominal), OECD 202
Key value for chemical safety assessment
Additional information
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