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Diss Factsheets
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EC number: 223-810-8 | CAS number: 4083-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (based on immediate and violent reactivity of PTSI with water): irritating to skin
Eye irritation (based on immediate and violent reactivity of PTSI with water): irritating to eyes
Respiratory irritation (based on immediate and violent reactivity of PTSI with water): irritating to respiratory tract
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The results of PTSA are not read across to PTSI. PTSI is extremely reactive with water and reacts instantaneously into the source substance PTSA. This will readily occur on the skin and also in the eye upon exposure to PTSI. Thus, although final exposure will be to PTSA and not PTSI, the initial violent reaction of PTSI with water justifies its classification for skin and eye irritation. Moreover, due to its extreme reactivity it is considered unethical to perform the skin and eye irritation/corrosion studies on animals with PTSI as such.
According to Annex VI of CLP, PTSI is also classified as irritating to the respiratory tract.
Justification for selection of skin irritation / corrosion endpoint:
A pre-GLP study similar to the OECD Guideline 404, but with some deviations, with PTSA, the direct reaction product of PTSI, showed that PTSA is not irritating to skin. However, because of the immediate violent exothermic reactivity of PTSI with water/moisture, it is considered appropriate to classify PTSI for skin irritation.
Justification for selection of eye irritation endpoint:
A pre-GLP study similar to the OECD Guideline 405, but with some deviations, with PTSA, the direct reaction product of PTSI, showed that PTSA is not irritating to eyes. However, because of the immediate violent exothermic reactivity of PTSI with water/moisture, it is considered appropriate to classify PTSI for eye irritation.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Based on its extreme reactivity with water, PTSI is considered to meet the criteria for classification and will require labelling for skin and eye irritation in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP) and Annex VI of 67/548/EEC (DSD).
Based on Annex VI of 1272/2008/EC (CLP), PTSI is also considered to meet the criteria for classification and will require labelling for respiratory irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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