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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-770-5 | CAS number: 99-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Brown Norway
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 315.143 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight.
- Executive summary:
The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.971
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 2.06
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 315.143 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Test type:
- other: Acute Rodent Inhalation Toxicity Test
- Species:
- rat
- Strain:
- other: Wistar;Sprague-Dawley;CnR-CD;Long-Evans
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: Inhalation: Vapor
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 218.23
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.
- Executive summary:
The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.
Reference
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.347
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 3.45
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 218.23 mg/m³ air
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.
Additional information
Acute toxicity oral
The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.
The various weight of evidence studies can be summarised as follows :
Acute toxicity : oral |
Sr. No |
End point |
Species |
Effect level |
1 |
LD50 |
Rattus norvegicus |
2315.143 mg/kg of body weight
|
|
2 |
LD50 |
Peromyscus maniculatus |
2028.969 mg/kg of body weight |
|
3 |
LD50 |
Rat |
2250 mg/kg |
|
4 |
LD50 |
Mouse |
1060 mg/kg |
|
5 |
LD50 |
Rabbit |
1000 mg/kg |
|
6 |
LD50 |
Rat |
704 mg/kg |
Acute toxicity inhalation
The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.
Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (LD50) of 5-nitro-o-anisisdine in rat was found to be 2315.143 mg/kg of body weight. This value indicates that 5 -nitro-o-anisidine does not exhibit acute toxicity by the oral route.
Justification for selection of acute toxicity – inhalation endpoint
The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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