Serine, 2-[(2,3,4-trihydroxyphenyl)methylene]hydrazide, hydrochloride (1:1)

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Principles of method if other than guideline:

Particle size distribution was determined by LASER diffraction using a HELOS Particle Size Analyser.

GLP compliance:

no

Type of distribution:

other: LASER diffraction

Test material

Test material information

Constituent 1

Reference substance name:

2-amino-3-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanehydrazide hydrochloride

EC Number:

940-411-0

Cas Number:

1353749-74-2

Molecular formula:

C10H14ClN3O5

IUPAC Name:

2-amino-3-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanehydrazide hydrochloride

Details on test material:

- Purity: 99.9%

Results and discussion

Particle size

Particle size 1

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size 2

Percentile:

D10

Mean:

0.71 µm

Particle size 3

Percentile:

D50

Mean:

2.03 µm

Particle size 4

Percentile:

D90

Mean:

24.11 µm

Any other information on results incl. tables

The physical state of the test substance at 20°C and 101.3 kPa is determined to be a light yellowish crystalline powder at visual examination. Microscopy examination showed the crystals to appear as needle-shaped crystals with a tendency to form agglomerates.

 

Particle size distribution by percentile
X10µm	X50µm	X90µm
0.71	2.03	24.11

Applicant's summary and conclusion

Conclusions:

This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
Particle distribution by percentile: D10 - 0.71, D50 - 2.03 and D90 - 24.11 µm

Executive summary:

Particle size distribution was determined by laser diffraction using a HELOS Particle Size Analyser. The particle sizes at the 10^th , 50^th, and 90^th percentiles were, respectively, 0.71, 2.03 and 24.11 µm.