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Diss Factsheets
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EC number: 208-015-6 | CAS number: 505-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Unfortunately no experimental data regarding toxikocinetics of 1,3-dioxepane exists.
There is no specific requirement to generate TK information in REACh. Annex I, Section 1.0.2 states that “the human health hazard assessment shall consider the toxicokinetic profile (i.e. absorption, metabolism, distribution and elimination) of the substance”. Furthermore, REACh announces in Annex VIII (Section 8.8.1) that one should perform “assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information”.
Absorbtion
Oral
From the molecular weight of 102.13 g/mol, the log Pow of 0.6 (at 20 °C) and a good water solubility of 263 g/l (at 20°C) a considerable absorption of dioxepane in the GI-tract can be anticipated.
Inhalation
At room temperature 1,3 -dioxepane in a liquid and based on the vapor pressure of 20 hPa at 18.5°C a significant vapor exposure needs to be taken into account.
Based on the already mentioned physico-chemical properties of dioxepane (molecular weight of 102.13 g/mol, log Pow of 0.6 and water solubility of 263 g/l) a considerable absorption can also be anticipated for the inhaled vapor in the respiratory tract. Furthermore water soluble vapors like dioxepane can be effectively removed from the air in the upper respiratory tract.
Dermal
Dermal absorption represents the amount of topically applied substance that is found in the epidermis (stratum corneum excluded) and in the dermis, and this quantity is therefore taken as systemically available. Again, based on the physico-chemical properties of dioxepane (molecular weight of 102.13 g/mol, log Pow of 0.6 and water solubility of 263 g/l) a considerable dermal absorption can not be excluded, even tough an in silico prediction (DERMWIN v2.00) resulted in a dermal permeability coefficient (Kp) of 0.00105 cm/hr, indicating a low dermal uptake.
Based on the high vapor pressure of dioxepane (20 hPa at 18.5°C), the extend of the vapor partitioning from the air into the stratum corneum is limited by evaporation.
Accumulative potential
Although there is no direct correlation between the lipophilicity of a substance and its biological half-life, substances with high log P values tend to have longer half-lives unless their large volume of distribution is counter-balanced by a high clearance. On this basis, there is the potential for highly lipophilic substances (log P >4) to accumulate in individuals that are frequently exposed (e.g. daily at work) to that substance. Since for dioxepane the log Pow is 0.6, no significant accumulative potential in adipose tissue needs to be anticipated.
Metabolism
In an in vitro assay the formaldehyde-formation out of dioxepane and the fate of formaldehyde was assayed under the conditions of in vitro cytogenicity studies (BASF AG, 1998). Incubations were performed with and without a metabolic activation system (S9-mix). Detectable amounts of formaldehyde were formed in the incubations with S9-mix but not in the absence of S9-mix. A direct extrapolation to the in vivo metabolisation is difficult, but the formation of formaldehyde particularly in metabolicaly active tissues (e.g. the liver) can not be excluded.
Excretion
Substances that are excreted in the urine tend to be water-soluble and of low molecular weight. Substances that are excreted in the bile tend to have higher molecular weights. Based on the molecular weight of 102.13 g/mol and a good water solubility of 263 g/l (at 20°C) a predominant excretion via the urine can therefore be anticipated. To a certain extend vapors are likely to be additionally excreted via the exhaled air. Furthermore a low lipid solubility can be derived from the log Pow of 0.6, and therefore no distinct concern for high dioxepane concentrations in the breast milk exists.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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