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EC number: 269-348-0 | CAS number: 68227-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
According to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Part 3 Chapter 3.1 no classification required, since this substance does not cause concern of acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Five groups of five male albino rats of the Sherman-Wistar
Strain weighing between 200 and 300 gm were employed in
this study. The rats were deprived of food but not water
for 24 hours prior to dosing. Each animal was weighed and
dosed by direct administration of the experimental material
into the stomach by means of a syringe and dosing needle. - GLP compliance:
- not specified
- Remarks:
- test done before GLP was established
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Each animal was dosed by direct administration of the experimental material
into the stomach by means of a syringe and dosing needle. - Doses:
- 1 g/kg
2 g/kg
4 g/kg
8 g/kg
16 g/kg - No. of animals per sex per dose:
- five animals (males) per dose
- Control animals:
- no
- Details on study design:
- Five groups of five male albino rats of the Sherman-Wistar
Strain weighing between 200 and 300 gm were employed in
this study. The rats were deprived of food but not water
for 24 hours prior to dosing. Each animal was weighed and
dosed by direct administration of the experimental material
into the stomach by means of a syringe and dosing needle. - Statistics:
- The subject material when studied in male albino rats has
an acute oral LD of 12.9 gm/kg. with 19/20 Confidence
~imits of from 8?8 to 20.1 gm/kg. - Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 12 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 8 400 - < 20 100
- Mortality:
- one animal within 24 hours in the 8 g group
one animal within 24 hours and two within 48 hours in the 16 g group - Clinical signs:
- other: At the dosage levels of 1.0 and 2.0 gm/kg. the animals were ruffled, dirty and slightly depressed after 24 hours. They appeared recovered and normal after 48 hours. At the dosage level of 4.0 gm/kg. the animals were depressed after 4-6 hours. Within 24 ho
- Gross pathology:
- In the gross pathologic examination, slight hemorrrhaging of the GI tract was evident in those animals dying during
the course of the study. Gross pathologic examination of the animals sacrificed a t the conclusion of the observation
period revealed nothing remarkable. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The subject material when studied in male albino rats has an acute oral LD50 of 12.9 gm/kg. with 9/20 Confidence limits of from 8.4 to 20.1 gm/kg.
- Executive summary:
The subject material when studied in male albino rats has an acute oral LD50 of 12.9 mg/kg. with 19/20 Confidence limits of from 8.4 to 20.1 gm/kg.
Reference
Dosage Level g/kg | Number of Animals Dosed | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | Total Dead 14 Days | Total Survived 14 Days | Average Initial Weight [g] | Average Final Weight [g] |
1.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 235 | 280 |
2.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 220 | 250 |
4.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 240 | 275 |
8.0 | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 210 | 235 |
16.0 | 5 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 220 | 245 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 12 900 mg/kg bw
- Quality of whole database:
- Study has been done before the establishment of GLP, but is supported by a study on a category member which is following the Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association. Klimisch score 2.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One group of ten (5 male and 5 female) albino rats was used in this study. The rats were placed in a 70 liter, all glass exposure chamber and exposed to a saturated atmosphere of the test material in air for one hour. The material was administered as an aerosol. the material was heated gently to approximately 135°F (57°C) to facilitate aerosolizing. The rate of flow was 10.0 liters per minute at a temperature of 70°F (21°C). The air was passed threough a desicant prior to being passed through the test material. By differential weighing it was calculated that the rats were subject to concentration of 20.1 mg/liter during the exposure period. This is an average value over the one hour period.
- GLP compliance:
- no
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 male & 5 female albino rats
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Chamber
- Exposure chamber volume: 70 liter - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- differential weighing
- Duration of exposure:
- 14 d
- Concentrations:
- 20.1 mg/liter
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 20.1 mg/L air (nominal)
- Mortality:
- none
- Clinical signs:
- other: Immediately after exposure the animals were ruffled, wheezing and dirty. Within 24 hours they appeared recovered and normal.
- Body weight:
- Average initial weight: 210 gr males and 205 gr females
Average final weight: 255 gr males and 230 gr females - Gross pathology:
- Gross pathologic examination revealed nothing remarkable.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From the results obtained in this study using the method described above, it appears that the subject material has an LC50 greater than 20.1 mg/liter, the maximum concentration which could attained.
Reference
total dead 14 days: 0
total survived 14 days: 10 (all)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 20 000 mg/m³ air
- Quality of whole database:
- Study has been done before the establishment of GLP, but is supported by a study on a category which member following the Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association. Klimisch score 2.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Section 173.240 (a) (1) and Appendix A
- Principles of method if other than guideline:
- One group of six (3 male and 3 female) albino rabbits weighing between 2.0 and 3.0 kg each was employed in this study. All animals had their back clipped free of hair 24 hours prior to testing. All of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied.
The following dosage level was administered: 1.0 mg/kg.
All rabbits were weighted and the correct amount of experimental material was applied to the back of each animal. These treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal. The dressings were removed after twenty-four hours and any excess material was removed and the approximate amount remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities. Gross autopsies were performed onall animals which died during the 14 day observation period and also on all survivors of the 14 day observation period. - GLP compliance:
- no
- Test type:
- fixed dose procedure
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 3 males and 3 females
- Type of coverage:
- other: gauze patches for 24 hours
- Vehicle:
- other: none
- Details on dermal exposure:
- 24 hours
- Duration of exposure:
- 24 hours
- Doses:
- 1.0 gr/kg bw
- No. of animals per sex per dose:
- 3 male
3 female - Control animals:
- no
- Preliminary study:
- no prelimenary study
- Sex:
- male/female
- Dose descriptor:
- other: corrosion
- Effect level:
- > 1 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: very slight edema and erythema
- Interpretation of results:
- study cannot be used for classification
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 1 mg/kg bw
- Quality of whole database:
- Study has been done before the establishment of GLP, but is supported by a study on a category member which meets the criteria set forth in Regulation EC No. 440/2008 for filling REACH endpoints and is of high quality, Klimisch score = 1. The data is generated in a reliable laboratory using established protocols. This data valid as documented CCRF for this category (Acetylenic geminalic diols).
Additional information
There is no data gap.
According to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Part 3 Chapter 3.1 no classification required, since this substance does not cause concern of acute toxicity.
Justification for selection of acute toxicity – oral endpoint
Only one study available.
Justification for selection of acute toxicity – inhalation endpoint
Only one study available.
Justification for selection of acute toxicity – dermal endpoint
Only one study available.
Justification for classification or non-classification
According to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Part 3 Chapter 3.1 no classification required, since this substance doese not cause concern of acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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