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Diss Factsheets
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EC number: 209-264-3 | CAS number: 563-80-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A pre-GLP, static, limit study and a modern OECD 202 static renewal study conducted according to GLP.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Two aquatic invertebrate studies are available for Methyl Isopropyl Ketone (MIPK). The first study was a pre-GLP study conducted as a limit test at a nominal 100 mg/L concentration under static, non-renewal conditions with simultaneous exposure of 6 invertebrate species and one fish species. In this study daphnia were exposed for 48 hours and all of the other species were exposed for 96 hours. 50% mortality did not occur in any of the species tested, therefore the LC50 was reported as >100 mg/L. Due to concerns for volatility of the test substance, a recent OECD 202 study with daphnia was conducted using a static renewal system with multiple concentrations up to 100 mg/L nominal. In this study initial and final test solutions were measured daily. Some losses of the test substance occurred during the study and the mean measured concentration for the highest exposure was 81 mg/L. 5% immobilization was observed in the highest concentration but this was not considered an adverse response from exposure to the test substance. Therefore, the NOEC was reported as 81 mg/L and the LC50 was > 81 mg/L, the highest concentration tested. Based upon a weight of evidence from these two studies it is believed that the LC50 for aquatic invertebrates is ≥ 100 mg/L.
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