Registration Dossier
Registration Dossier
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EC number: 275-069-5 | CAS number: 70969-58-3
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity
Acute toxicity to fish has been investigated in a 96 hour test and the LC50 (96h) determined to be 3.69 mg/L (nominal concentration), 2.22 mg/L (measured concentration). (Q)SAR estimation indicates a LC50 of 0.932 mg/L, lower than the experimentally determined value.
Acute immobilisation in Daphnia has been investigated in a 48 hour test and the EC50 (48h) was determined to be 3.58 mg/L. (Q)SAR estimation indicates an EC50 of 1.33 mg/L, lower than the experimentally determined value.
Algal growth inhibition has been investigated in a 72 hour test and the EC50 values for inhibition of specific growth rate (ErC50) and yield (EyC50) was >6.9 mg/L. The NOEC for inhibition of specific growth rate (ErC0) and yield (EyC0) was 3.9 mg/L. (Q)SAR estimation indicates an EC50 of 0.418 mg/L, lower than the experimentally determined value.
A respiration inhibition test with activated sludge has been conducted according to OECD Guidelines. No significant inhibition was observed and the EC50 was was regarded as being > 1000 mg/L.
Long-term toxicity
Data on long-term toxicity are not available. (Q)SAR modeling has been used, the ECOSAR model being a reliable and appropriate (Q)SAR model to apply to diisobutyl hexahydrophthalate, as it is based on a chemical dataset that calculates the toxicity of esters, which exhibit excess toxicity in addition to narcosis. The predicted long-term (32-33 day) toxicity ChV for fish is 0.042 mg/L and the predicted long-term (21-day) toxicity ChV for daphnid is 0.405 mg/L. In view of this model over predicting short-term toxicity, these predictions may be regarded as reasonable.
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