1-(3-chlorophenyl)-4-(3-chloropropyl)piperazinium chloride

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Evaluation of antimicrobial effect of test material

GLP compliance:

not specified

Test organisms (species):

Escherichia coli

Details on inoculum:

Strain :50 and 90

Test type:

static

Water media type:

freshwater

Dose descriptor:

other: MIC

Effect conc.:

128 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: For two strain 50 and 90 the MIC was observed in the range of 64-128 mg/l

Dose descriptor:

other: MIC

Effect conc.:

> 512 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: For two strain 50 and 90 the MIC was observed to be 512 mg/l

Conclusions:

For two strain 50 and 90 the MIC was observed in the range of 128-512 mg/l

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microroganism of the test chemical.The studies are as mentioned below:

The effect of test material was evaluated for microorganism Escherichia coli (Strain 50 and 90) , for two strain 50 and 90 the MIC was observed in the range of 64-128 mg/l. varied effect was observed on both the stains of test organism.

For another functionally similar read across substance ,the effect of test material was evaluated for microorganism Escherichia coli (Strain 50 and 90) , for two strain 50 and 90 the MIC was observed to be 512 mg/l. varied effect was observed on both the stains of test organism.

Description of key information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microroganism of the test chemical.The studies are as mentioned below:

The effect of test material was evaluated for microorganism Escherichia coli (Strain 50 and 90) , for two strain 50 and 90 the MIC was observed to be 256 mg/l. varied effect was observed on both the stains of test organism.

For another functionally similar read across substance ,the effect of test material was evaluated for microorganism Escherichia coli (Strain 50 and 90) , for two strain 50 and 90 the MIC was observed to be >512 mg/l. varied effect was observed on both the stains of test organism.

Key value for chemical safety assessment

EC50 for microorganisms:

512 mg/L

Additional information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microroganism of the test chemical.The studies are as mentioned below:

The effect of test material was evaluated for microorganism Escherichia coli (Strain 50 and 90) , for two strain 50 and 90 the MIC was observed to be 256 mg/l. varied effect was observed on both the stains of test organism.

For another functionally similar read across substance ,the effect of test material was evaluated for microorganism Escherichia coli (Strain 50 and 90) , for two strain 50 and 90 the MIC was observed to be >512 mg/l. varied effect was observed on both the stains of test organism.