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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on developmental toxicity

Additional information

Oral administration of 0.4, 2.0, 10.0, 25.0 and 50.0 mg/kg/day of 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (i.e. the racemate) to pregnant rats from 7 days to day 17 of gestation produced no maternal or foetal effects in a preliminary teratogenicity study. The only available data is from a brief summarised secondary source, and as such is considered to be unreliable and inadequate for risk assessment and classification purposes.

Justification for classification or non-classification

The data described above are inadequate for classification and labelling. However the following information is relevant for classification and labelling of this substance:

Fluazifop-P-butyl (CAS No: 79241-46-6; butyl (R)-2-[4-(5-trifluoromethyl-2-pyridyloxy) phenoxy]propionate) is an active substance used in plant protection products.

Fluazifop-P (CAS# 83066-88-0; (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid; i.e. the same substance as defined in section 1) is the major systemically available metabolite of the active substance.

Fluazifop-P-butyl is listed in Regulation (EC) 1272/2008, Annex VI (Table 3.1: list of harmonised classification and labelling of hazardous substances and Table 3.2: list of harmonised classification and labelling of hazardous substances from Annex I to Directive 67/548/EEC) with Index No. 607-305-00-3.

The corresponding information on classification and labelling with respect to reproductive toxicity are:

Table 3.1: Repr. 2; H361d

Table 3.2: Repr. Cat. 3; Xn, R63


There is strong evidence to suggest that fluazifop-P-butyl rapidly metabolizes in vivo to fluazifop-P. For this reason the test(s) with the active substance which lead(s) to the classification mentioned above can in principle also be considered as a test performed with fluazifop-P. For this reason the corresponding classification and labelling with respect to reprotoxicity of the active substance is also adopted for fluazifop-P.

Additional information