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EC number: 271-878-2 | CAS number: 68610-86-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 27 JAN 1975 to 03 FEB 1975.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FDA guideline (Fed. Reg. Vol. 37, No. 38, 1972)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-, N,N'-bis(o-anisyl and 2,4-xylyl) derivs.
- EC Number:
- 271-878-2
- EC Name:
- Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-, N,N'-bis(o-anisyl and 2,4-xylyl) derivs.
- Cas Number:
- 68610-86-6
- Molecular formula:
- C36H34Cl2N6O4 // C35H32Cl2N6O4 // C34H30Cl2N6O6
- IUPAC Name:
- 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(2,4-dimethylphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-N-(2,4-dimethylphenyl)-3-oxobutanamide; 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(2,4-dimethylphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-N-(2-methoxyphenyl)-3-oxobutanamide; 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(2-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-N-(2-methoxyphenyl)-3-oxobutanamide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Housing: individually
- Diet: mixed feed ERKA 8300 (Robert Koch, Hamm) ad libitum
- Water: tap water, ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 ml - Duration of treatment / exposure:
- 24 h (5 animals, group 1); 5 min (3 animals, group 2)
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 8
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: with 300 ml water for 2 min
- Time after start of exposure: 24 h (5 animals, group 1); 5 min (3 animals, group 2)
SCORING SYSTEM: basically in accordance with OECD TG 405
TOOL USED TO ASSESS SCORE: fluorescein, UV-lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: group 1 + group 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: group 1 + group 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1 - #4, group 1
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Remarks:
- group 1
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks:
- 72 h after application.
- Remarks on result:
- other: redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Remarks:
- group 2
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks:
- 72 h after application.
- Remarks on result:
- other: redness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 7-8, group 2
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: redness
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: group 1 + group 2
- Irritant / corrosive response data:
- 24-h-exposure (5 animals, group 1):
No corneal or iridial effects were noted during the study.
Every animal showed slight conjunctival redness of score 1 one hour after application.
Animal #5 showed conjunctival redness of score 1 at 1, 24 and 48 h after application.
Slight chemosis of score 1 was observed in animals #1 and #5 one hour after application.
No other effects were observed in animals #1 - #4.
At 72 h no effects were observed in any animal.
5-min-exposure (3 animals, group 2):
No corneal or iridial effects were noted during the study.
Every animal showed slight conjunctival redness of score 1 one hour after application.
Animal #6 showed conjunctival redness of score 1 at 1, 24 and 48 h after application.
Slight chemosis of score 1 was observed in animal #6 one hour after application.
No effects were observed in animals #7 and #8.
At 72 h no effects were observed in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP regulation
- Conclusions:
- According to the classification criteria of Regulation (EC) No 1272/2008 the test material is not irritating to eyes under these test conditions. This conclusion is legitimate as 5 animals (group 1) were tested basically in accordance with today's standard methods regarding dosing, exposure duration, scoring system, reading time points and the observed eye responses were fully reversible 72 hours after application.
- Executive summary:
The test material was subject to a test of eye irritancy according to FDA guideline (Fed. Reg. Vol. 37, No. 38, 1972). 0.1 ml of neat test substance were placed the conjunctival sac of one eye each of 8 rabbits and washed out after 24 h (5 animals, group 1) or after 5 min (3 animals, group 2) and the effects were observed for seven days. No corneal or iridial effects were noted during the study. Slight conjunctival redness was observed, fully reversible by 72 h, and slight chemosis only one hour after application. As the mean values of the observed eye responses fall below the critical values for classification according to the criteria of Regulation (EC) No 1272/2008, the test material is not irritating to eyes and has not to be classified for eye irritation.
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