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Diss Factsheets
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EC number: 260-375-3 | CAS number: 56773-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study according OECD 434 draft
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Principles of method if other than guideline:
- Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test item applied semiocclusively for 24 hours. Mortality and clinical signs were examined during a 14 d post-observation period. analimals. After termination of the study a gross pathology was performed.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Tetraethylammonium heptadecafluorooctanesulphonate
- EC Number:
- 260-375-3
- EC Name:
- Tetraethylammonium heptadecafluorooctanesulphonate
- Cas Number:
- 56773-42-3
- Molecular formula:
- C8H20N.C8F17O3S
- IUPAC Name:
- N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate
- Details on test material:
- tetraethylammonium perfluorooctesulfonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
dose mg/kg bw toxicological result* occurrence of signs time of death mortality (%)
male
2000 1/5/5 8d-14d 11d 20
female
2000 0/5/5 2d-14d -- 0
* number of animals which died spontaneously and/or were sacrificed in moribund state / number of animals with signs of toxicity / total number of animals used per group
Clinical Signs
The following clinical signs were observed:
piloerection, sunken flanks, temporary clonical cramps and loss of weight in males,
a partial reddening of the test area and loss of weight in females
Body Weights
On day 8 of the study a severe loss of weight in all male animals was detected. At the end of the study all surviving male animals have had balanced the loss of weight.
A severe loss of weight in all female animals was detected. At the end of the study all females have increased the body weight but don’t have balanced the loss of weight.
The weights are given in the appendix as individual and mean values on page 24, for body weight gain see page 25.
Gross Pathology Findings
One male animal died on day 11 of the observation period.
The following changes were detected: liver and kidneys were light discolored.
The gross pathology investigations performed at the end of the post-treatment observation period in the surviving male animals and the females did not revealed any treatment-related findings
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information
- Executive summary:
Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test item applied semiocclusively for 24 hours. Mortality and clinical signs were examined during a 14 d post-observation period. analimals. After termination of the study a gross pathology was performed.
LD50 rat, male, female : > 2000 mg/kg body weight,
The following clinical signs were observed: piloerection, sunken flanks, temporary clonical cramps and loss of weight in males,
a partial reddening of the test area and loss of weight in females; one male animal died on day 11 of the observation period.
The following changes were detected: liver and kidneys were light discolored.
The gross pathology investigations performed at the end of the post-treatment observation period in the surviving male animals and the females did not revealed any treatment-related findings.
According to the OECD TG 434 for GHS a classification as Acute Tox 5, H313 (may be harmful in contact with skin). However, this classification for acute dermal toxicity has no relevance for EU countries, because in EU countries such an classification did not exist.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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