Registration Dossier
Registration Dossier
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EC number: 203-052-4 | CAS number: 102-77-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable , well-documented publication which meets basic scientif principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of 2-thiobenzothiazoles in the rat, urinary fecal and billary metabolites of 2-benzothiazyl sulfenamides
- Author:
- Fukuoka, M.; et al.
- Year:
- 1 995
- Bibliographic source:
- Arch. Toxicol., 70, 1-9
Materials and methods
- Objective of study:
- excretion
- metabolism
- Principles of method if other than guideline:
- other: evaluation of excretion and metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(morpholinothio)benzothiazole
- EC Number:
- 203-052-4
- EC Name:
- 2-(morpholinothio)benzothiazole
- Cas Number:
- 102-77-2
- Molecular formula:
- C11H12N2OS2
- IUPAC Name:
- 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
- Details on test material:
- N-oxydiethylene-2-[14C]-benzothiazyl sulfenamide
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C-ODBS
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- DMSO
Doses / concentrations
- Remarks:
- Doses / Concentrations:
250 mg/kg
- No. of animals per sex per dose / concentration:
- 3 or 5 male rats
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- The compound given orally to rats, was rapidly excreted in the urine and feces
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- five urinary metabolites: 2-mercaptobenzothiazole (MBT), its three conjugates, mercapturate, glucuronide and sulfate, 2-mercaptobenzothiazole disulide
Any other information on results incl. tables
The metabolic fate of the test article in rats was studied using tracer techniques. The compound given orally to rats, was rapidly excreted in the urine and feces. Five urinary metabolites, (2-mercaptobenzothiazole, its three conjugates mercapturate, glucuronide and sulfate, and 2 -mercaptobenzothiazole disulfide) were confirmed. 2-mercaptobenzothiazole disulfide was also found as a fecal metabolite. The test compound was partially transformed in the stomach to 2-mercaptobenzothiazole disulfide,which was predominately excreted into feces. In the liver, the test compound was mainly transformed to 2-mercaptobenzothiazole and its conjugates. The S-glucuronide and S-sulfate conjugates were predominately excreted into bile.
14C was rapidly absorbed , as indicated blood peak levels at 15 to 30 min after administration and undergo enterohepatic circulation
Applicant's summary and conclusion
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