2-chloroacetamide

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: clinical cases

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was not conducted according to regulatory guidelines and only contained limited information, therefore it is considered relevant but less reliable and adequate for classification.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Contact allergy to chloracetamide

Author:

Klaschka F

Year:

1975

Bibliographic source:

Contact Dermatitis (1975) 1, 265-266

Materials and methods

Study type:

clinical case study

Endpoint addressed:

skin sensitisation

Principles of method if other than guideline:

Patch tests for contact allergens

Test material

Test material information

Constituent 1

Reference substance name:

2-chloroacetamide

EC Number:

201-174-2

EC Name:

2-chloroacetamide

Cas Number:

79-07-2

Molecular formula:

C2H4ClNO

IUPAC Name:

2-chloroacetamide

Details on test material:

Chloroacetamide was provided by the manufacturer

Method

Type of population:

general

occupational

Subjects:

1) 57-year-old female pensioner
2) 43-year-old female worker

Route of exposure:

dermal

Reason of exposure:

other: unintentional, 1) non-occupat. 2) occupational

Exposure assessment:

not specified

Details on exposure:

1) pensioner: cosmetic skin cleanser used, which contained chloroacetamide
2) worker in contact with wet cork, treated with 0.5 % chloroacetamide as disinfectant

Examinations:

Dermal clinical examination

Results and discussion

Clinical signs:

1) pensioner using skin cleanser: inflammatory reddening and swelling of the skin of the face, neck, nape and neck-line, on the back of her hands and forearms ascending to the middle of the upper arms.
2) worker in contact with wet cork: the first two fingers of her right hand showed an eczematous reaction, which improved during periods of time off and deteriorated after returning to work. Dermatitis spread to other fingers and to the back of her right hand causing deeper rhagades.

Results of examinations:

Only on 1) pensioner using skin cleanser:
Patch tests performed with contact allergens chosen on the basis of the case history were negative, except
a) for a facial cleanser presently used b) for another cosmetic skin cleanser used previously for more than one year.

Effectivity of medical treatment:

1) resistent

Any other information on results incl. tables

Two case studies were described in which Chloroacetamide was determined to be a skin sensitizer: 1) a pensioner using skin cleanser developed inflammatory reddening and swelling of the skin of the face, neck, nape and neck-line, on the back of hands and forearms ascending to the middle of the upper arms: a patch test containing facial cleanser was positive; 2) a worker in contact with wet cork developed an eczematous reaction on the fingers of the right hand, which improved during periods of time off and deteriorated after returning to work.

Applicant's summary and conclusion

Conclusions:

In both cases, chloroacetamide was a contact sensitizer.