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Diss Factsheets
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EC number: 237-163-4 | CAS number: 13676-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- According to REACH Annex XI column 2, “9.2. Further biotic degradation testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the degradation of the substance and its degradation products. The choice of the appropriate test(s) depends on the results of the chemical safety assessment and may include simulation testing in appropriate media (e.g. water, sediment or soil).”
The 'ready' biodegradability of the test item was investigated in the Manometric Respirometry Test, according to OECD Guideline 301 F, EC 440/2008 C.4 -D, and GLP principles. A nominal test concentration of 50 mg O2/L ThOD was used. There was no oxygen consumption and no biodegradation in two replicates after 28 days, 0% degradation was stated.
In the available hydrolysis study according to OECD 111, the substance was determined to be hydrolytically unstable under acidic, neutral and basic conditions, the rate of the reaction increasing with increase in pH. A DT50 value of 12 hours was obtained at pH 4, 2 hours at pH 7 and a DT50 value of less than 5 minutes was obtained at pH 9.
N-Phenyl imide was identified via EpiSuite estimation as the potentially hydrolysable group, no further hydrolysable groups were identified.
So it can be concluded, that the substance is hydrolytically unstable, but not biodegradable, which also applies to potential hydrolysis products. This is proven by the biodegradation test of the actually registered substance, in combination with the short hydrolysis half-life of 2h at neutral pH.
With regard to sediment, although the substance is not likely to undergo significant biotic biodegradation in the environment, it is likely to have a high mobility. A Soil Adsorption Study performed by HPLC method calculated a soil adsorption coefficient, Koc of 970 (log Koc= 3.0). On this basis the substance would not be expected to adsorb onto sediment.
According to REACH Annex IX column 1, Sediment simulation testing is required for substances with a high potential for adsorption to sediment, which is not the case here and testing can hence be omitted.
In consequence it can reasonably be assumed that further testing, e.g. Aerobic mineralisation in surface water - simulation biodegradation test (test method: EU C.25./OECD TG 309) would result in no or not relevant additional degradation, and testing can be omitted as no further relevant results could be obtained.
Data source
Materials and methods
Results and discussion
- Transformation products:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.