Registration Dossier
Registration Dossier
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EC number: 612-179-8 | CAS number: 61597-98-6
Endpoint summary
Administrative data
Description of key information
Additional information
A valid study on the acute toxicity of menthyl lactate to fish is available on zebra fish. A 96-hour LC50 value of 22 mg/L was found in this study. The substance had low toxicity to aquatic freshwater invertebrates. The 48-hour EC50 value with daphnids was greater than 125 mg/L. The corresponding effect level for the major breakdown product of menthyl lactate in water - L-menthol - was a 48-hour EC50 value of 26.6 mg/L in daphnids. A study on algal toxicity of menthyl lactate is not available and this endpoint was covered with a valid study on the structurally related substance menthyl acetate. The ErC50 value after 72 hours was 2.7 mg/L, the ErC10 value was 0.61 mg/L, and the NOEC (growth rate) 0.16 mg/L. This corresponds to an ErC50 value of 3.11 mg/L, an ErC10 of 0.7 mg/L, and a NOEC of 0.18 mg/L for menthyl lactate. The freshwater alga therefore represents the most sensitive species with regard to acute exposure to the substance. The hazard assessment is based on the effect levels of the algal study and the PNECs aqua will be derived from the ErC50 value of 3.11 mg/L. A valid respiration inhibition test is available. The EC50 value was 650 mg/L after 3 hours and this is used in the hazard assessment.
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