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Diss Factsheets
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EC number: 231-194-7 | CAS number: 7446-08-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Case Report
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No significant deficiencies in study design and evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from selenite
- Author:
- Senff H et al
- Year:
- 1 988
- Bibliographic source:
- Contact dermatitis, 1988, 19/1, 73 -74
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin sensitisation
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium selenite
- EC Number:
- 233-267-9
- EC Name:
- Sodium selenite
- Cas Number:
- 10102-18-8
- Molecular formula:
- H2O3Se.2Na
- IUPAC Name:
- disodium selenite
- Details on test material:
- - Name of test material (as cited in study report): Sodium selenite
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- One female technician
15 control subjects not further specified - Ethical approval:
- not specified
- Route of exposure:
- dermal
Results and discussion
- Results of examinations:
- Positive patch test in one technician
Negative in 15 control persons
Any other information on results incl. tables
A laboratory technician had worked in the culture medium kitchen of a veterinary research institute.
After 6 months small severely-pruritic vesicles were occurred between the fingers, which were excoriated and healed without scarring. Similar symptoms then reappeared every 6 to 8 weeks (later on, even if gloves were worn) whenever she worked with the selenite-cystine enrichment broth.
Hand eczema improved or healed at weekends and during time away from work.
Symptoms increased after she had worked for 2 years in the culture-medium kitchen. Apart from eczema on the hands, eczema now also affected the face and neck, with watering eyes. Additionally two asthma attacks occurred within 2 month.
Patch testing with a standard series, disinfectants, preservatives and drugs was negative. The selenite-cystine enrichment broth and its individual ingredients were tested.
Sodium selenite showed a threefold positive reaction down to an aqueous dilution of 1:1000. There were no other positive reactions. Intracutaneous testing with common inhalants and the individual ingredients of the selenite –cystine enrichment broth was negative.
RASTs for common inhalants using peptone and selenite were negative.
The same tests in 15 control subjects were also negative.
Applicant's summary and conclusion
- Conclusions:
- Positive patch test in one female technician, however RASTs for common inhalants using peptone and selenite were negative.
The same tests in 15 control subjects were also negative.
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