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Diss Factsheets
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EC number: 203-253-7 | CAS number: 104-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Cited as secondary source in a peer reviewed journal. Basic data given.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Appraisal of sensitizing powers by maximization testing in humans
- Author:
- Kligman AM
- Year:
- 1 971
- Bibliographic source:
- Report to RIFM, cited in Opdyke DLJ, Food Cosmet. Toxicol., Fragrance Raw Materials Monographs, Vol. 12: 239, 1974
- Reference Type:
- secondary source
- Title:
- Appraisal of sensitizing powers by maximization testing in humans. Report to RIFM
- Author:
- A.M.Kligman
- Year:
- 1 971
- Bibliographic source:
- Cited in RIFM Database, Location 1805;
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Human maximization study was conducted on 25 male volunteers.
- GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted.
Test material
- Reference substance name:
- 4-methylanisole
- EC Number:
- 203-253-7
- EC Name:
- 4-methylanisole
- Cas Number:
- 104-93-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 1-methoxy-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): p-Methylanisloe
- Analytical purity: no data given
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 25
- Sex: male
- Age: no data given
- Race: no data given - Clinical history:
- no data
- Controls:
- no data
- Route of administration:
- dermal
- Details on study design:
- Closed patch applications with the test material in petrolatum were made to the same site on the volunteers´forearms for 5 alternate day 48-hour periods.
Patch sites were pretreated with 5 % sodium lauryl sulphate (SLS) for 24 hours.
Following a 10 day rest period, challenge patches were applied to fresh sites under occlusion for 48 hours and the challenge sites were pretreated for 1 hour with 10 % SLS under occlusion.
The sites were read at patch removal (48 h) and 48 h after patch removal (72 h).
Results and discussion
- Results of examinations:
- According to the authors, no sensitization effects were seen when using 2 % of the test material.
In the 48-hour closed patch test, performed prior to the human maximization study, no irritating effects were observed using 2 % of the test material.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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