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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 263-214-5 | CAS number: 61792-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Specific investigations: other studies
Administrative data
- Endpoint:
- phototoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1 March 1983 to 3 March 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The objective of the study was to determine the phototoxic potential of Lemonile to the skin in guinea pigs.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- (2Z/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2Z/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (2Z/6E)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2Z/6E)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (2E/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2E/6Z)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (2E/6E)-3,7-dimethylnona-2,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (2E/6E)-3,7-dimethylnona-2,6-dienenitrile
- Reference substance name:
- (3E/6Z)-3,7-dimethylnona-3,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (3E/6Z)-3,7-dimethylnona-3,6-dienenitrile
- Reference substance name:
- (3E/6E)-3,7-dimethylnona-3,6-dienenitrile
- Molecular formula:
- C11H17N
- IUPAC Name:
- (3E/6E)-3,7-dimethylnona-3,6-dienenitrile
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
impurity 1
impurity 2
Test animals
- Species:
- guinea pig
- Strain:
- other: Himalayan white spotted
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Institute Biological Research, Füllinsdorf, Switzerland
- Weight at study initiation: 300 - 450 g
- Housing: Wire mesh cages
- Diet: Pellet standard NAFAG No. 844, CH-9202, Switzerland
- Water: tap water available ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 °C
- Humidity (%): 45 ± 10%
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12 hours light per day
- Light source: UV-lamp Westinghouse FS 40 "Black Lamp", energy 10⁴ ergs/cm2/s , spectrum 320 nm - 400 nm wavelength, giving a radiation dose of 20 J/cm²
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- DMSO
- Details on exposure:
- INDUCTION PHASE
Both flanks of 10 guinea pigs were shaved by electric clippers at a minimum of 2 hours before the chemical was applied to the test site. Thereafter, a maximum of 5 test sites of 2 cm2 were marked on both flanks by circular stamp. To 4 test areas the test material was applied and the fifth test site was treated with a 0.1% alcoholic solution of 8MOP and serves as a control.
Thirty minutes after application of the test material the left flank of experimental animals was exposed to non-erythemogenic UV-A irradiation. The test sites on the right flanks remain unexposed after treatment and serve as control sites.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10% test material plus 2% DMSO
Basis:
nominal conc.
- No. of animals per sex per dose:
- 10 animals
- Control animals:
- yes, concurrent no treatment
Examinations
- Examinations:
- Reading and grading of skin responses was performed 4, 24 and 48 hours after application of the test material for signs of erythema and edema.
- Scoring system:
-- 0. No reaction
-- 1. Defined erythema
-- 2. Erythema and defined oedema
-- 3. Marked erythema and oedema - Positive control:
- 8 MOP
Results and discussion
- Details on results:
- See Table 1
Any other information on results incl. tables
Table 1:Results data
Animals |
Left flank: irradiated with 20 J UV-A/cm2 |
Right flank: no irradiation (controls) |
||||||||||
Treated with test material |
Treated with 0.1% 8 MOP |
Treated with test material |
Treated with 0.1% 8 MOP |
|||||||||
Reading of reactions |
Reading of reactions |
Reading of reactions |
Reading of reactions |
|||||||||
4 h |
24 h |
48 h |
4 h |
24 h |
48 h |
4 h |
24 h |
48 h |
4 h |
24 h |
48 h |
|
1-10 |
0 |
0 |
0 |
1 |
2 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
Grading scale: 0 = no reaction
1 = slight reaction
2 = well-defined reaction
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions used, Lemonile showed no photoxic potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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