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Diss Factsheets
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EC number: 201-304-8 | CAS number: 80-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 January to 21 January 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study carried out in compliance with an internationally recognised guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent: Day 0, Day 2, Day 5
- Sampling method: 5µL of test solution taken and injected into a high performance liquid chromatograph
- Sampling methods for the volatile compounds, if any: test solutions kept in 10ml vacuum vials filled to the top and hermetically sealed
- Sampling intervals/times for pH measurements: not relevant, the substance contains no ionisable groups
- Sampling intervals/times for sterility check: day 0 and Day 5
- Sample storage conditions before analysis: not relevant samples analysed immediately - Buffers:
- - pH: 4.0; 7.0; 9.0
- Type and final molarity of buffer: pH4 0.2M acetic acid/0.2M sodium acetate; pH7and 9 0.1M potassium dihydrogenphosphate and 0.05M borax;
- Composition of buffer:
pH 4.0 buffer solution: prepared by mixing 255 mL of 0.2M acetic acid and 57 mL of 0.2M sodium acetate in water.
pH 7.0 buffer solution: prepared by mixing 198 mL of 0.1M potassium dihydrogenphosphate in water and 118 mL of 0.05M borax in water.
pH 9.0 buffer solution: prepared by mixing 54 mL of 0.1M potassium dihydrogenphosphate in water and 250 mL of 0.05M borax in water. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 10 ml vacuum vials hermetically closed with rubber stopper and screw cap
- Sterilisation method: autoclave, 120°C, 1hour
- Lighting: not applicable
- Measures taken to avoid photolytic effects: test vessels protected from light by wrapping in aluminium foil
- Measures to exclude oxygen: test solutions deaeration by bubbling nitrogen gas through sterilized 0.2µm membrane filters for 5 minutes
- Details on test procedure for unstable compounds: not applicable
- If no traps were used, is the test system closed/open: closed (hermetically sealed vacuum vials
- Is there any indication of the test material adsorbing to the walls of the test apparatus?: no
TEST MEDIUM
- Volume used: 10ml
- Kind and purity of water: lab reagent grade, sterilised
- Preparation of test solution: One mL of the test substance was measured into a 100 mL volumetric flask and made up to volume with sterile water to prepare the stock test solution. Two mL of the stock test solution was measured into a 200-mL volumetric flask and made up to volume with sterilized/deaerated buffer. The solutions obtained were used as test solutions. Each test solution was pipetted into ten 10 mL vacuum vials, 10 mL per vial , and hermetically closed with a rubber stopper and screw cap.
- Renewal of test solution: not applicable
- Identity and concentration of co-solvent: not applicable
OTHER TEST CONDITIONS
The prepared test solutions were held in a thermostatic water bath set at 50°C for the duration of the test. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 105.26 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 105.08 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 104.84 mg/L
- Number of replicates:
- Two per time point and pH
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- The preliminary study showed that the test substance was stable in water at pH 4, 7 and 9.
The main study was not required. - Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- No measurable hydrolysis was seen during the study
- % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 100.3
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Other kinetic parameters:
- Not applicable no measurable hydrolysis was seen during the study
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
- Anomalies or problems encountered (if yes): None
MAJOR TRANSFORMATION PRODUCTS
Not applicable, the substance is stable to hydrolysis
MINOR TRANSFORMATION PRODUCTS
Not applicable, the substance is stable to hydrolysis
INDICATION OF UNSTABLE TRANSFORMATION PRODUCTS:
Not applicable, the substance is stable to hydrolysis
PATHWAYS OF HYDROLYSIS
Not applicable, the substance is stable to hydrolysis
SUPPLEMENTARY EXPERIMENT (if any): RESULTS:
Not applicable, the substance is stable to hydrolysis - Validity criteria fulfilled:
- yes
- Conclusions:
- The substance is stable to hydrolysis at pH 4.0, 7.0 and 9.0
Reference
Description of key information
The substance is stable to hydrolysis at pH 4.0, 7.0 and 9.0
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The substance is stable to hydrolysis for 5 days at 50°C in a preliminary hydrolysis test carried out in accordance with OECD test Guideline 111. Further work is not undertaken as it can be concluded from the results of the preliminary test that the substance will have a half-life time of greater than 1 year at 25°C at pH 4, 7 and 9.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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