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Diss Factsheets
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EC number: 500-311-6 | CAS number: 120498-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Derek analysis
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- DEREK for Windows 13.0.0
- GLP compliance:
- no
Test material
- Reference substance name:
- N-butyl-2,2,6,6-tetramethylpiperidin-4-amine, oligomeric reaction products with N,N'-bis(3-aminopropyl)ethylenediamine and 2,4,6-trichloro-1,3,5-triazine
- EC Number:
- 500-311-6
- EC Name:
- N-butyl-2,2,6,6-tetramethylpiperidin-4-amine, oligomeric reaction products with N,N'-bis(3-aminopropyl)ethylenediamine and 2,4,6-trichloro-1,3,5-triazine
- Cas Number:
- 120498-03-5
- IUPAC Name:
- 1,3-Propanediamine,N-N’’-1,2-ethanediylbis- reaction product with 1,3,5-triazine-2,4-diamine,N,N’-dibutyl-6-chloro-N,N’-bis(2,2,6,6-tetramethyl-4-piperidinyl), polymer with N-butyl-4,6-dichloro-N-(2,2,6,6-tetramethyl-4-piperidinyl)-1,3,5-triazin-2-amine
Constituent 1
Results and discussion
Any other information on results incl. tables
This alert describes the hepatotoxicity of 2,4-diamino substituted 1,3,5-triazines and is based primarily on 28-day repeat-dose study data contributed by a Lhasa Limited member. These compounds have been reported to cause hepatocellular damage observed as hypertrophy, single cell necrosis and vacuolization of hepatocytes, increases in liver weight, elevation of hepatic enzymes and cholesterol levels and damage to the bile canaliculi in experimental animals. The mechanism of toxicity remains unknown but it could be associated with their
metabolism. The metabolic routes of these compounds in humans and rodents involve primarily N-dealkylation reactions of the nitrogen side chains and/or glutathione conjugation [1, 2]. In vitro hepatotoxicity studies on fresh isolated hepatocytes and primary cultured hepatocytes of ametryn and prometryn gave a positive response for cytotoxicity characterised by decreased levels of glutathione content in the cells and increased levels of lactate dehydrogenase [3].
Applicant's summary and conclusion
- Conclusions:
- DEREK for Windows 13.0.0 predicts that hepatotoxicity is PLAUSIBLE in human and mammal due to Alert 651 – 2,4-Diamino-1,3,5-triazine. HA88 is a very large dimer derived from 2,4,6-triamino-1,3,5-triazine, more commonly known as melamine (CAS number 108-78-1). As indicated in the alert description in the DEREK for Windows 13.0.0 output report (attached), whether HA88 has any potential for hepatotoxicity is likely to depend on how the compound is metabolised.
A dendrimer based on melamine has been reported to produce hepatotoxicity in acute and subchronic studies in mice [4]. However, the same group of workers showed that such dendrimers can reduce the hepatotoxicity of solubilised cancer drugs administered by intraperitoneal injection [5].
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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