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EC number: 230-279-6 | CAS number: 7005-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 Nov - 02 Dec 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. The documentation of materials and methods, and results is limited.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- limited documentation
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(dimethylamino)-2-methylpropan-1-ol
- EC Number:
- 230-279-6
- EC Name:
- 2-(dimethylamino)-2-methylpropan-1-ol
- Cas Number:
- 7005-47-2
- Molecular formula:
- C6H15NO
- IUPAC Name:
- 2-(dimethylamino)-2-methylpropan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-Dimethylamino-2-methyl-1-propanol, 73% DMAMP, Polymeen A (P-2614)
- Substance type: clear, pale yellow liquid
- Analytical purity: 72.03%
- Lot/batch No.: 730H18DF36
- pH: 12.5
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Cox-SD albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 187 ± 8.8 g
- Fasting period before study: yes
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: test substance is soluble in the vehicle (water) - Doses:
- 950, 1500, 1900, 2400 and 3000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the animals were observed for mortality and signs of toxicity several times during the first day after dosing and daily thereafter. All animals were weighed before dosing, on day 7 and on day 14.
- Necropsy of survivors performed: yes. Animals that died during the study period were necropsied immediately and the surviving animals were necropsied after sacrifice on day 14.
In a range-finding study, the maximum dose possible to administer was 3000 mg/kg bw. Therefore this was selected as the highest dose in the main study. - Statistics:
- The oral LD50 values, the 95% confidence limits (shown in parenthesis), and the slope (+SE) were calculated according to Finney (Probit Analysis, Cambridge University Press, 1971) adapted to BASIC computer program.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 656 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 395 - 1 878
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 767 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 600 - 1 946
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 712 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 950 mg/kg bw: 1/10 males and 0/10 females died
1500 mg/kg bw: 1/10 males and 4/10 females died
1900 mg/kg bw: 7/10 males and 7/10 females died
2400 mg/kg bw: 10/10 males and 9/10 females died
3000 mg/kg bw: 10/10 males and 10/10 females died
Most of the animals died within 24 hours of dosing, while one female administered 2400 mg/kg bw and 2 males administered 1900 mg/kg bw died on day 5, 5 and 6, respectively. The mortality was caused by the local irritating effect of the test substance, as the main findings were hemorrhaging in the stomach and intestines. - Clinical signs:
- other: 1500 mg/kg bw: lethargy, eye squint, hunched posture, and ataxia by the fourth hour after dosing in females, fully reversible within 24 h. 1900 mg/kg bw: lethargy, eye squint, hunched posture, and ataxia by the fourth hour after dosing in females and male
- Gross pathology:
- In the animals that died during the study period, the stomach and intestine were severely haemorrhaged. These effects are probably due to local irritation by the very alkaline test substance.
The presence of dark organs is not dose-related and may be a result of the method of sacrifice (the method was not reported).
1900 mg/kg bw: 5/10 males and 6/10 females had a dark spleen, while 1/10 females also had dark adrenals
2400 mg/kg bw: 3/10 females had a dark spleen
3000 mg/kg bw: 4/10 females had a dark spleen, kidneys and adrenals
One female administered 950 mg/kg bw had severe lung infection. This is not considered to be a treatment-related effect, as only one animal had this condition and no dose-related trend was observed. All other organs were grossly normal.
Any other information on results incl. tables
Table 1. Results, acute oral toxicity study
Dose |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Males |
||||
950 |
1/0/10 |
- |
Day 5 |
10 |
1500 |
1/0/10 |
- |
Day 1 |
10 |
1900 |
7/10/10 |
3 h – day 5 |
Day 1 (5 rats), Day 5 (1 rat), Day 6 (1 rat) |
70 |
2400 |
10/10/10 |
1 h - death |
Day 1 |
100 |
3000 |
10/10/10 |
1 h - death |
Day 1 |
100 |
LD50 = 1767 mg/kg bw (male) |
||||
|
||||
Females |
||||
950 |
0/0/10 |
--- |
--- |
0 |
1500 |
4/10/10 |
3 h – day 1 |
Day 1 |
40 |
1900 |
7/10/10 |
3 h – day 6 |
Day 1 |
70 |
2400 |
9/10/10 |
2 h - death |
Day 1 (8 rats) and 5 (1 rat) |
90 |
3000 |
10/10/10 |
1 h - death |
Day 1 |
100 |
LD50 = 1656 mg/kg bw (female) |
* first number = number of dead animals
second number = number of animals with clinical signs
third number = number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: Acute oral toxicity 4, H302
DSD: Xn, R22
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