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Diss Factsheets
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EC number: 608-271-2 | CAS number: 28861-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990-1991
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP. 20 cells were examined instead of 100 cells/animals recommendation. 2 doses were checked instead of 3 doses. Dose selection was not met guideline requirement.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Deviations:
- yes
- Principles of method if other than guideline:
- 20 cells were examined instead of 100 cells/animals recommendation.
2 doses were checked instead of 3 doses.
Dose selection was not met guideline requirement. - GLP compliance:
- no
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Tyrosine, N-(aminocarbonyl)-3-methoxy-O,α-dimethyl-
- EC Number:
- 608-271-2
- Cas Number:
- 28861-00-9
- Molecular formula:
- C13H18N2O5
- IUPAC Name:
- Tyrosine, N-(aminocarbonyl)-3-methoxy-O,α-dimethyl-
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: CLFP
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 30 g (average weight)
- Assigned to test groups randomly: [no/yes, under following basis: ] 2 test groups and 1 vehicle control, 1 positive control group, 1 unchanged control group
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- - Vehicle(s)/solvent(s) used: oleum helianthi (sunflower oil)
- Justification for choice of solvent/vehicle:
- Concentration of test material in vehicle:
- Amount of vehicle (if gavage or dermal):
- Type and concentration of dispersant aid (if powder):
- Lot/batch no. (if required):
- Purity: - Duration of treatment / exposure:
- 24 h, 48 h
- Frequency of treatment:
- 1 treatment/test group
- Post exposure period:
- 24 h/50 % of the test animals
48 h/50 % of the test animals
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
250 mg/bwkg
Basis:
other: 1/20 x LD50
- Remarks:
- Doses / Concentrations:
125 mg/bwkg
Basis:
other: 1/40 x LD50
- No. of animals per sex per dose:
- 1st test group, 250 mg/bwkg, 20 animals
2nd test group, 125 mg/bwkg, 20 animals
vehicle control group, 0.1 mL oleum helianthi/animal, 20 animals
Positive control group, 100 mg/kg Cyclophosphamide, 10 animals
Unchanged control, 10 animals - Control animals:
- yes, concurrent no treatment
- yes, concurrent vehicle
- Positive control(s):
- cyclophosphamide
- Justification for choice of positive control(s): no data
- Route of administration: oral, gavage
- Doses / concentrations: 100 mg/bwkg
Examinations
- Tissues and cell types examined:
- mouse bone marrow, from femur
- Details of tissue and slide preparation:
- DATTA and co-workers (1970), Wurster (1972).
- Statistics:
- Fisher-probe, Delanuois (1979).
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Experimental results has not shown genotoxic effects in the examined doses of the test substance.
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