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EC number: 275-702-5 | CAS number: 71617-10-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 December 1994 to 15 December 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Isopentyl p-methoxycinnamate
- EC Number:
- 275-702-5
- EC Name:
- Isopentyl p-methoxycinnamate
- Cas Number:
- 71617-10-2
- Molecular formula:
- C15H20O3
- IUPAC Name:
- isopentyl p-methoxycinnamate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: SPF albino
- Details on test animals or test system and environmental conditions:
- Animals = Four female SPF albino rabbits weighting 2.1-2.4 kg of the stock Mol:Russian from Mollegaard Breeding and Research Centre A/S, Ejby, DK-4623 Lille Skensved were used.
Housing = The study took place in animal room No. 1 provided with filtered air with a temperature of 21±3°C, relative humidity of 55±15% and air changes 10 times/h. The room was illuminated to give a 24 h cycle of 12 h light and 12 h darkness. Ligh was on from 6 a.m. to 6 p.m. During a pre-period of at least 1 week and throughout the experiment, the rabbits were caged in single 62 x 52 cm PPO cages with perforated floor.
Diet = A pelleted complete rabbit diet "Altromin 2123" from Chr. Petersen, DK-4100 Ringsted, Denmark was available ad libitum. Analyses for major nutritive components and significant contaminants are performed regularly on the diet.
Drinking water = The animals had free access to bottles with domestic quality drinking water acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth. Analyses for possible contaminants are performed regularly.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- other: Ethanol 96 % and diethyl phtalate (DEP) in a ration 1 : 1 (w/w)
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- Test concentrations (w/w): 100, 20, 10, 5, and %
- Duration of treatment / exposure:
- After an exposure of 4 h, the tape and patches were removed and the treated skin was cleaned with soap and luke warm water. The skin reactions were read 1 hour later.
- Observation period:
- After an exposure of 4 hours the tape and patches were removed and the treated skin was cleaned with soap and luke warm water. The skin reactions were read 1 h later.
Reading was also performed at 24, 48, and 72 h after termination of exposure. - Number of animals:
- Four female SPF albino rabbits were used.
- Details on study design:
- The day before the experiment was started, the rabbits were weighted and an area of 10 x 10 cm on the back was clipped as closely as possible with an electric clipper.
On the experimental day, the rabbits were physically restrained on a test table, and the clipped area was divided into 6 test sites: 2 anterior located test sites, 2 centrally located test sites and 2 posterior located test sites. To each of 6 gauze patches (2.5 x 2.5 cm), 0.5 mL of 1 of the test concentrations or the vehicle was applied and the patches were placed on the appropriate test site at the back of each rabbit. The gauze patches were secured with a semi-occlusive dressing by means of a 1-cm wide adhesive tape and fixed with Scanpor tape, 4.5 cm width, loosely wound round the trunk. The application schedule was made by a computerized randomization programme.
After an exposure of 4 h, the tape and patches were removed and the treated skin was cleaned with soap and luke warm water. The skin reactions were read 1 h later. Reading was also performed at 24, 48, and 72 h after termination of exposure.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- see section "Any other information on results incl. tables" below
- Other effects:
- no other effects were observed
Any other information on results incl. tables
Under the experimental conditions described in the report, the mean score for erythema and oedema in the 4 rabbits used were as follow:
Test concentration | 100 % |
20 % |
10 % |
5 % |
1 % |
Vehicle |
Erythema |
0.3 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
Oedema |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Isopentyl p-methoxycinnamate was found to be not irritating to the skin of rabbits.
- Executive summary:
The primary skin irritant effect of Neo Heliopan E1000 was investigated according to the method recommended in the current OECD guideline no. 404, "Acute Dermal Irritation/ Corrosion", 1992, and in the current EC guideline B.4 "Acute toxicity (skin irritation)", dated 29.12.1992. The study was extended to investigate 5 different concentrations of the test article and a vehicle control on each animal.
Four albinos rabbits were exposed to different concentrations of the test article at 6 skin sites on the back. After 4 h of exposure, the test article was removed and the skin was examined 1, 24, 48, and 72 h after termination of exposure.
Slight skin erythma was observed at 1 to 48 h after termination of exposure of the neat test article. Apart from that, no abnormalities were observed.
Accordingly, isopentyl p-methoxycinnamate was rated as being not irritating to the skin of rabbits.
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