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Diss Factsheets
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EC number: 231-810-4 | CAS number: 7747-35-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The primary skin irritation study was conducted in six albino rabbits. The skin on the backs was shaved free of hair. The test site was covered with a gauze pad after applying undiluted test material. The skin reactions were scored immediately after cleaning the test sites (24 hours) and at the end of 72 hours (48 hours after first scoring).
- GLP compliance:
- no
Test material
- Reference substance name:
- 7a-ethyldihydro-1H,3H,5H-oxazolo[3,4-c]oxazole
- EC Number:
- 231-810-4
- EC Name:
- 7a-ethyldihydro-1H,3H,5H-oxazolo[3,4-c]oxazole
- Cas Number:
- 7747-35-5
- Molecular formula:
- C7H13NO2
- IUPAC Name:
- 7a-ethyl-tetrahydro-1H-[1,3]oxazolo[3,4-c][1,3]oxazole
- Details on test material:
- - Name of test material (as cited in study report): P-1601 (Oxazolidine E, BIOBANTM CS-1246 Antimicrobial)
- Physical state: Light yellow coloured liquid
- Analytical purity: 94.52%
- Lot/batch No.: M4590
- Stability under test conditions: Not reported assumed to be stable under normal storage conditions
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: 2.2 ± 0.1 kg
- Housing: Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: left side of the middorsal line was left intact while the skin on the right side was abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mg of test material was applied to each site.
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 72 hr (48 hr after the first scoring)
- Number of animals:
- 6
- Details on study design:
- Primary skin irritation evaluations were conducted with 6 rabbits. The skin on the backs was shaved free of hair. The skin on the left side of the middorsal line was left intact, and skin on the right side was abraded by scratching the skin in a tic-tac pattern with a blunt needle. The abrasions were through the stratum corneum, but not deep enough to disturb the derma or induce bleeding.
A 0.5mg sample of the material was applied to each site and covered with a gauze pad. The entire trunk was wrapped with a rubberized cloth and a flexible wire screen held in place with tape.
After the 24-hour exposure, the bindings and patches were removed and the treated sites cleaned. The skin reactions were scored immediately (24 hours) and at the end of 72 hours (48 hours after first scoring).
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 5.7
- Remarks on result:
- other: Severe irritation
- Irritant / corrosive response data:
- Refer attachment: Table 4. Primary skin irritation scores in the treated rabbits
- Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The compound produced erythema and edema on the intact and abraded sites. The average irritation score was 5.7, and therefore the material is considered be a severe irritant to skin.
- Executive summary:
Primary skin irritation evaluations were conducted with 6 rabbits. The skin on the backs was shaved free of hair. The skin on the left side of the middorsal line was left intact, and skin on the right side was abraded by scratching the skin in a tic-tac pattern with a blunt needle. The abrasions were through the stratum corneum, but not deep enough to disturb the derma or induce bleeding.
A 0.5 mg sample of the material was applied to each site and covered with a gauze pad. The entire trunk was wrapped with a rubberized cloth and a flexible wire screen held in place with tape.
After the 24-hour exposure, the bindings and patches were removed and the treated sites cleaned. The skin reactions were scored immediately (24 hours) and at the end of 72 hours (48 hours after first scoring).The compound produced erythema and edema on the intact and abraded sites. The average irritation score was 5.7, and therefore the material is considered be a severe irritant to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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