Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 310-012-0 | CAS number: 102110-14-5 A complex combination of hydrocarbons obtained by distillation of steam-cracked naphtha. It consists predominantly of hydrocarbons having carbon numbers in the range of C3 through C6, predominantly C5.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study available as unpublished report, no restrictions, fully adequate for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): toluene, MRD-91-918
- Physical state: colourless liquid
- Analytical purity: no information
- Expiration date: February 1996
- Storage condition of test material: room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: HRP, Inc, Denver, PA, USA
- Age at study initiation: males approx 12-13 weeks, females approx 11-12 weeks
- Weight at study initiation: 2.24-2.95 kg
- Housing: single housed in suspended stainless steel and wire mesh cages
- Diet: Agway certified diet RCA Rabbit (pellets) ad libitum
- Water: ad libitum via automatic system
- Acclimation period: at least 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature: approx 18-21°C
- Humidity: 40-60%
- Air changes (per hr): no information
- Photoperiod: 12 hrs dark /12 hrs light
IN-LIFE DATES: From: 4 October 1994 To: 11 October 1994
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Single application
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 (4 male and 2 female)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): NA - eyes were unwashed.
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: 2% sodium fluorescein under UV light
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: n/a
- Remarks on result:
- other: no corneal effects
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: n/a
- Remarks on result:
- other: mild iritis in 3 animals at 1 hour only
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.4
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: scores of 2 or 3 in all animals at 24 hours, 1 or 2 in all animals at 48 hours and 1 in 4 animals at 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: minimal chemosis in 5 animals at 24 hour and persisting until 48 hours in 2 animals
- Irritant / corrosive response data:
- There were no corneal effects and iridial effects were limited to 3 animals at the 1 hour observation only. At 1 hour conjunctival redness, chemosis, and discharge were observed in all animals. Redness was observed in all animals at 24 and 48 hours and in four animals at 72 hours. Chemosis was observed in five animals at 24 hours and two animals at 48 hours. Discharge was observed in four animals at 24 hours. In addition, dye retention of the nictitating membrane was observed in three animals at 24 hours and one at 48 hours. All conjunctival effects had recovered by day 7.
- Other effects:
- Clinical signs were not observed in any animal and all animals survived to study termination
Any other information on results incl. tables
Mean ocular irritation scores for each observation interval
|
1 hour |
24 hour |
48 hour |
72 hour |
7 day |
Corneal opacity |
0 |
0 |
0 |
0 |
0 |
Iritis |
0.5 |
0 |
0 |
0 |
0 |
Conjunctival redness |
3.00 |
2.17 |
1.50 |
0.67 |
0 |
Chemosis |
3.33 |
0.83 |
0.33 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- Toluene is not irritating to the rabbit eye.
- Executive summary:
The eye irritation potential of toluene was evaluated following a single 0.1 mL instillation to the right eye of 6 New Zealand White rabbits. The treated eyes of all animals remained unwashed. Observations for signs of ocular irritation and toxicity were made at 1, 24, 48, and 72 hours post-instillation and on Day 7.
There were no corneal effects and iridial responses were limited to three animals at 1 hour. Toluene elicited conjunctival irritation in all animals from 1 hour which persisted until 72 hours in 4 animals but was fully recovered by day 7.
Toluene is slightly irritating to the rabbit eye but no classification is warranted under Dir 67/548/EEC or GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)