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EC number: 203-505-6 | CAS number: 107-58-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- To determine acute oral toxicity of test chemical in mice
- Author:
- Kazuo Hashimoto et. al.
- Year:
- 1 981
- Bibliographic source:
- Archives of Toxicology
- Reference Type:
- review article or handbook
- Title:
- ACUTE ORAL TOXICITY STUDY IN MICE
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
- Reference Type:
- other: Authoritive database
- Title:
- Acute oral toxicity study of test chemical in mice
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- secondary source
- Title:
- acute oral toxicity study of test chemical in mice
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The acute toxicity of the test chemical by oral administration in mice was determined according to Weil (1952), using four animals per dosage level and four different doses.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- N-tert-butylacrylamide
- EC Number:
- 203-505-6
- EC Name:
- N-tert-butylacrylamide
- Cas Number:
- 107-58-4
- Molecular formula:
- C7H13NO
- IUPAC Name:
- N-tert-butylacrylamide
- Details on test material:
- - Name of test material (IUPAC name): 2-Propenamide, N-(1,1-dimethylethyl)-
- Common name: N-tert-butylacrylamide
- Molecular formula: C7H13NO
- Molecular weight: 127.1857g/mol
- Smiles notation: CC(C)(C)NC(=O)C=C
- InChl: 1S/C7H13NO/c1-5-6(9)8-7(2,3)4/h5H,1H2,2-4H3,(H,8,9)
- Substance type: Organic
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ddY
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 29 2.2 g body weight
- Housing: Animals were randomly placed in plastic cages (5-7 per cage) containing wooden flakes.
- Diet (e.g. ad libitum): laboratory chow, ad libitum
- Water (e.g. ad libitum): water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- no data
- Doses:
- 5.6 - 9.7 mmol/kg (712.23 - 1233.7 mg/kg bw)
- No. of animals per sex per dose:
- 4 animals per dose
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- The acute toxicity of the test compounds by oral administration in mice was determined according to Weil (1952).
Results and discussion
- Preliminary study:
- no data
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 941.174 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 712.23 - 1 233.7
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% Mortality was observed in treated mice at 941.174 mg/kg bw.
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 914.174 mg/kg bw, with 95% confidence limit of 712.23 - 1233.7 mg/kg, when male ddy strain mice were treated with the given test chemical orally.
- Executive summary:
Acute oral toxicity study was performed by using the given test chemical in Male mice of ddY strain at the dose concentration of 5.6 - 9.7 mmol/kg (712.23 - 1233.7 mg/kg bw). The given test chemical was dissolved in DMSO and administered via oral route. Animals were 5-6 weeks of age and 29 ± 2.2 g body weight at the beginning of the experiment and were randomly placed in plastic cages (5-7 per cage) containing wooden flakes. They were fed laboratory chow and water ad libitum. The acute toxicity of the test compounds by oral administration in mice was determined according to Weil (1952). 50% Mortality was observed in treated mice at 941.174 mg/kg bw. Therefore, the lethal concentration (LD50) value for acute oral toxicity test was considered to be 914.174 mg/kg bw, with 95% confidence limit of 712.23 - 1233.7 mg/kg, when male ddy strain mice were treated with the given test chemical orally.
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