Registration Dossier
Registration Dossier
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EC number: 219-292-8 | CAS number: 2403-89-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- other: read across
- Type of information:
- other: OECD Toolbox v3.4 read across study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,2,6,6-pentamethylpiperidin-4-ol
- EC Number:
- 219-292-8
- EC Name:
- 1,2,2,6,6-pentamethylpiperidin-4-ol
- Cas Number:
- 2403-89-6
- Molecular formula:
- C10H21NO
- IUPAC Name:
- 1,2,2,6,6-pentamethylpiperidin-4-ol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Modified maximum average score
- Basis:
- mean
- Score:
- ca. 80
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks on result:
- other: Ecosar class aliphatic amines, STRICT; very strong confidence with p=4.49E-04
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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