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Diss Factsheets
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EC number: 264-092-6 | CAS number: 63310-16-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Skin irritation = Not irritating, rabbit, OECD 404, EU method B.4, Korenaga et al. (1983) & Bullock et al. (1982)
Eye irritation = Not irritating, rabbit, OECD 405, EU method B.5, Korenaga et al. (1983) & Bullock et al. (1982)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
SKIN
Two studies investigating the skin irritation potential of the test material were available. Both studies were conducted following a methodology equivalent to standardised guidelines OECD 404 and EU Method B.4. During the studies, six rabbits received 0.5 mL test material to two intact and two abraded sites for four hours (Korenaga et al., 1983) and twenty four hours (Bullock et al., 1982). All animals were assessed for the following 7 days for any signs of skin irritation. In the study reported by Korenaga et al., the test material caused no irritation, either to intact or abraded sites, but did stain the skin of all animals yellow. The primary irritation score was 0. The test material was subsequently concluded to be not irritating to the skin. In the study reported by Bullock et al., the test material caused well-defined to moderate erythema and very slight to moderate edema through 72 hours after treatment. At seven days after treatment, one animal had well defined erythema, and five out of six animals had dry and cracked skin. The overall irritation score was 4.3. The test material was subsequently concluded to be not irritating to the skin
EYE
Two studies investigating the eye irritation potential of the test material were available. Both studies were conducted following a methodology equivalent to standardised guidelines OECD 405 and EU Method B.5. During the studies 0.1 mL test material was applied into one eye of each of nine rabbits, the other eye remained untreated and served as a control. The treated and control eyes of three of the animals were rinsed with water 30 seconds after treatment. All animals were assessed for up to 7 days to determine the grade of ocular reaction. In the study reported by Korenaga et al., neither corneal opacity nor iritis was observed. The test material caused very slight to severe conjunctival irritation in all treated-unrinsed eyes one hour after dosing. Moderate conjunctival irritation was observed in all treated-rinsed eyes one hour after dosing. Both treated-unrinsed and treated-rinsed eyes appeared normal by the 72 hour reading. In consideration of the ocular effects observed it was concluded that the test material does not require classification as an eye irritant. In the study reported by Bullock et al., neither corneal opacity nor iritis was observed. The test material caused slight conjunctival irritation in treated-unrinsed animals, and two treated-rinsed animals, one hour after dosing. Both treated-unrinsed and treated-rinsed eyes appeared normal by the 24 hour reading. In consideration of the ocular effects observed it was concluded that the test material does not require classification as an eye irritant.
All studies presented to assess the irritation potential of the test material were performed in line with GLP and followed methodologies equivalent to those outlined in accepted standardised guidelines with a high standard of reporting. All studies were assigned a reliability score of 1 in accordance with the criteria for assessing data quality as outlined in Klimisch (1997) and considered suitable for assessment as an accurate reflection of the test material.
The available data are considered to be complete and the conclusion for both skin irritation, and eye irritation, not irritating, was taken forward for risk assessment.
Justification for selection of skin irritation / corrosion endpoint:
Two studies were available and both were considered as key studies.
Justification for selection of eye irritation endpoint:
Two studies were available and both were considered as key studies.
Justification for classification or non-classification
Skin
In accordance with with criteria for classification as defined in Annex I, Regulation 1272/2008, the test material is classified for skin irritation.
Eye
In accordance with the criteria for classification as defined in Annex I, Regulation 1272/2008, the test material does not require classification for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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