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EC number: 217-121-1 | CAS number: 1745-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
For oral and inhalation route, the default values from the REACH guidance (Chapter 8, R.8.4.2) are used fro DNEL derivation: 100% for inhalation, 50% for oral. Based on the log Kow of 4.12 and molecular weight of the substance, the skin permeability according to Fitzpatrick et al (2004) of the substance is considered to be moderately permeable to the skin. Therefore, a ratio of 0.5 for oral to dermal absorption is provisonally suggested for DNEL derivation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 25
- Absorption rate - inhalation (%):
- 100
Additional information
Toxocokinetic bahaviour:
The test item is a straw coloured viscous liquid. The low vapour pressure value (5.4 x 10E-5 Pa at 25°C, Tremain, 2014) and predicted negative explosive and oxidising properties (Tremain, 2014) shows that the substance is of low volatility therfore inhalation is not a significant route of exposure. The test item was indicated to be a sensitizer (Henzell, 2014). The results from the repeated dose reproductive screening study in rats (Fulcher, 2014) produced nephrotoxicty at 250 mg/kg bw/day, lower pregnancy rates et 750/500 mg/kg bw/day there waw no effect on offspring survival, growth and development rated but to a dosage of 500 mg/kg bw/day.
Absorption:
The lipophilic nature of the substance (Log Pow 4.12, O'Connor, 2014) would suggest that the gastro-intestinal tract provides a route of absorption, following oral administration, before entering the circulatory system via the blood. Limited absoption may also take place via the skin as the test item was shown to be sensitizer (Henzell, 2014) and the test item could penetrate the dermal membrane through damaged skin.
Distribution:
There was evidence of systemic toxicity following the conduct of a repeated dose reproductive screening study in the rat (Fulcher, 2014). Furthermore the positive response in a sensitization study suggests that the test item nmay bind to carrier proteins in the circulatory systems (Henzell, 2014), thereby facilitating systemic distribution.
Metabolism:
The results of the reproductive/developmental toxicity screening study performed in male and female rats exposed to the test item at dosage up to 750 (reduced to 500) mg/kg bw/day elicited histopathological evidence of abnormal hepatic metabolism, a condition associated with enhanced metabolism, a condition associated with enhanced metbolism. A dditionally, nephrotoxicity was identified at 250 mg/kg bw/day.
Excretion:
There is no evidence to indicate the route of excretion but low water-soluble products are not favourable for urinary excretion and therefore biliary excretion may be the most plausible route of excretion of the test item via the faeces. Metabolism of the parent material may involve rendering it
more water soluble thereby enhancing renal excretion. The neprotoxicity identified in the reproductive/developmental toxicity screening study (Fulcher, 2014) may therefore have been a consequence of the renal route being a point of excretion.
Conclusion:
The available information suggests that absorption of the test substance would take place from the gastrointestinal tract. Some limited absorption may also be possible through the skin. Once absorbed, the substance would be distributed via circulatory system and the faeces is the most probable route of excretion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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