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EC number: 230-257-6 | CAS number: 6990-43-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Justification for grouping of substances and read-across
There are no valid data available on the chronic toxicity towards aquatic invertebrates and toxicity towards algae and aquatic microorganisms of zinc O, O, O', O'-tetrabutyl bis(phosphorodithioate). In order to fulfil the standard information requirements set out in Annex VIII, Section 8.5.2, in accordance with Annex XI, Section 1.5 of Regulation (EC) No 1907/2006, read-across from a structurally similar substance is conducted.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met. ” In particular for human toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).
Having considered the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006, whereby physicochemical, toxicological and ecotoxicological properties may be predicted from data for reference substance(s) by interpolation to other substances on the basis of structural similarity, the substance Phosphorodithioic acid, mixed O, O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (CAS 84605-29-8) is selected as reference substances for the assessment of chronic toxicity towards aquatic invertebrates and toxicity towards algae and aquatic microorganisms.
The read-across is based on structural similarity as both chemicals belong to the substance class of Zinc alkyldithiophosphates (ZDDP) which are produced by a chemical reaction of Phosphorous pentasulfide with low molecular weight alcohols followed by a subseuqent reaction with zinc oxide. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
Overview of aquatic toxicity for the target substance Zinc O, O, O', O'-tetrabutyl bis(phosphorodithioate) and the source substance Phosphorodithioic acid, mixed O, O-bis(iso-Bu and pentyl) esters, zinc salts is presented in the following table.
|
Target substance (a) |
Source substance (b) |
CAS No. |
6990-43-8 |
84605-29-8 |
Chemical name |
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) |
Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts |
Short term toxicity to fish |
Experimental result: LC50 = 49 mg/L |
Experimental result: LL50 = 4.5 mg/L |
Long term toxicity to fish |
Data waiving |
-- |
Short term toxicity to aquatic invertebrates |
Experimental result: EC50 = 7.3 mg/L |
Experimental result: EL50 = 23 mg/L |
Long term toxicity to fish/invertebrates |
RA: CAS 84605-29-8 |
Experimental result: NOECreproduction = 0.26 mg/L |
Toxicity to aquatic algae |
RA: CAS 84605-29-8 |
Experimental result: ErL50 = 24 mg/L |
Toxicity to microorganisms |
RA: CAS 84605-29-8 |
Experimental result: EC50 > 10,000 mg/L |
(a) The substance subject to the REACh Phase-in registration deadline of 31 May 2013 is indicated in bold font. Only for this substance a full set of experimental results and/or read-across is given.
(b) Reference (read-across) substance(s) are indicated in normal font. Lack of data for a given endpoint is indicated by “--“.
Discussion:
Acute aquatic toxicity data for the target substance Zinc O, O, O', O'-tetrabutyl bis(phosphorodithioate) and the source substance Phosphorodithioic acid, mixed O, O-bis(iso-Bu and pentyl) esters, zinc salts established that invertebrate (i.e. Daphnia magna) is the most sensitive species with an EC50 (48h) of 7.3 mg/L (nominal). Thus Zinc O, O, O', O'-tetrabutyl bis(phosphorodithioate) is considered to be acutely toxic to aquatic organisms. Effects towards fish and algae were found in the same range providing an LC50 (96h) of 49 mg/L (nominal) for the rainbow trout (Salmo gairdneri) and an EL50 (72h) of 24 mg/L (nominal) for the growth inhibition of the green algae Scenedesmus subspicatus.
Long term data for the source substance Phosphorodithioic acid, mixed O, O-bis(iso-Bu and pentyl) esters, zinc salts towards invertebrate (i. e. Daphnia magna) determined a NOEC for reproduction of 0.26 mg/L (measured). No data on the long-term toxicity on fish is available. However, since daphnids can be considered as more sensitive towards this substance (compared to fish) and for reasons of animal welfare a chronic study with fish is not provided.
No inhibitory effects towards aquatic microorganisms were observed. Therefore, disturbances in sewage treatment plants are not anticipated for this substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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