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EC number: 431-250-2 | CAS number: 171850-30-9 ODCQA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single application of 2000 mg/kg test material was dermally applied to two rabbits under an impervious, occlusive bandage. Residual test substance was wiped off when the bandage was removed 24 hours after application. Test animals were observed for 14 days following test substance administration.
- GLP compliance:
- not specified
- Test type:
- other: similar to standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- EC Number:
- 431-250-2
- EC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Cas Number:
- 171850-30-9
- Molecular formula:
- C10H5NO3Cl2
- IUPAC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Details on test material:
- DCHQ-acid
Appearance: white solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No further information available on test animals and environmental conditions.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 0.5 % methylcellulose
- Details on dermal exposure:
- Animals were prepared 24 hours prior to dosing by clipping the trunk. A single application of 2000 mg/kg of neat test substance was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. 3.0 mL of 0.5% methylcellulose was used to moisten the test material to ensure sufficient contact of the test material with the skin. Residual test material was wiped off when the bandage was removed 24 hours after application.
- Duration of exposure:
- 24 hours
- Doses:
- 1 dose of 2000 mg/kg
- No. of animals per sex per dose:
- 2 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: test animals were weighed on days 1, 2, 8 and 15
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Both animals survived. There were no clinical signs indicative of systemic toxicity and no effect on bodyweight was noted.
- Mortality:
- Both animals survived the test period at the 2000 mg/kg dose level.
- Clinical signs:
- other: There were no clinical signs indicative of systemic toxicity.
- Other findings:
- Erythema and oedema were observed on both animals immediately after test material removal. One rabbit had erythema through test day three and the other rabbit had erythema through test day eleven.
Any other information on results incl. tables
Table 1: Bodyweights in kg
Animal number |
Test day 1 |
Test day 2 |
Test day 8 |
Test day 15 |
94A0966 |
3.96 |
3.82 |
3.94 |
4.11 |
94A3131 |
3.82 |
3.71 |
3.75 |
3.82 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the estimated acute dermal LD50 for male New Zealand White rabbits was greater than 2000 mg/kg.
- Executive summary:
Under the conditions of the study, the estimated acute dermal LD50 for male New Zealand White rabbits was greater than 2000 mg/kg.
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