Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-806-4 | CAS number: 5471-51-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-(4-hydroxyphenyl)butan-2-one
- EC Number:
- 226-806-4
- EC Name:
- 4-(4-hydroxyphenyl)butan-2-one
- Cas Number:
- 5471-51-2
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 4-(4-hydroxyphenyl)butan-2-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- other: Bovine
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Number of animals or in vitro replicates:
- 3 corneas for the test item
3 corneas as negative controls treated with physiological saline 0.9% NaCl
3 corneas as positive control treated with imidazole 20% in physiological saline 0.9% NaCl
Results and discussion
Any other information on results incl. tables
The eye irritancy potential of Raspberry Ketone was investigated in the bovine corneal
opacity and permeability assay.
Due to its solubility, the test item was directly applied and tested as provided by the
sponsor.
The following mean in vitro irritation score was calculated:
46.01
No prediction can be made regarding the classification of the test substance Raspberry
Ketone according to the evaluation criteria. Further testing in another suitable method is
required.
The in vitro irritation score obtained with the positive control fell within the two standard
deviations of the current historical mean and therefore this assay is considered to be
valid.
Applicant's summary and conclusion
- Interpretation of results:
- other: No prediction can be made regarding the classification of the test substance Raspberry Ketone according to the evaluation criteria. Further testing in another suitable method is required.
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- No prediction can be made regarding the classification of the test substance Raspberry
Ketone according to the evaluation criteria. Further testing in another suitable method is
required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
