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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment and conducted at a well respected institution (ICI Chemicals)

Data source

Reference
Reference Type:
publication
Title:
Acute Inhalation Toxicity of Some Halogenated and Non-halogenated Hydrocarbons
Author:
CLARK-DG; TINSTON-DJ
Year:
1982
Bibliographic source:
HUM-TOXICOL 1 239-247

Materials and methods

GLP compliance:
no
Test type:
other: EC50 for cardovascular effects

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,1-trichloroethane
EC Number:
200-756-3
EC Name:
1,1,1-trichloroethane
Cas Number:
71-55-6
Molecular formula:
C2H3Cl3
IUPAC Name:
1,1,1-trichloroethane
Details on test material:
Supplied by Imperial Chemical Industries PLC to commercial specification or AR grade laboratory chemicals.

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
yes
Remarks:
no results given
Duration of exposure:
ca. 5 min
Concentrations:
Various - not specified
Control animals:
no
Details on study design:
Animals observed for cardiac effects - no details of how measurements taken specified
Statistics:
The EC50 and 95% confidence intervals were calculated using the moving average technique of Thompson (1947)

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: EC50 (cardiac sensitisation)
Effect level:
ca. 0.7 other: vol % in air
Exp. duration:
5 min
Sex:
not specified
Dose descriptor:
other: EC 50 (CNS effects)
Effect level:
ca. 0.5 other: vol % in air
Exp. duration:
5 min
Clinical signs:
other: None reported
Other findings:
Specific details of cardiac sensitisation not given, but considered by author to be either ventricular tachycardia or ventricular fibrillation

Applicant's summary and conclusion

Conclusions:
1,1,1-trichloroethane was assessed as part of an investigation looking at the relationship between structure and activity for a number of halogenated and non-halogenated hydrocarbons.

Dogs were exposed for at least 5 minutes and observed for clinical signs and mortality. The number of dogs or concentrations is not specified. The EC50 for CNS effects in the dog was 0.5 vol % in air and for cardiac effects 0.7 % vol in air, following 5 minutes exposure.
Executive summary:

1,1,1-trichloroethane was assessed as part of an investigation looking at the relationship between structure and activity for a number of halogenated and non-halogenated hydrocarbons. 

Dogs were exposed for at least 5 minutes and observed for clinical signs and cardia effects.  The number of dogs or concentrations is not specified.  The EC50 for CNS effects in the dog was 0.5 vol % in air and for cardiac effects 0.7 % vol in air, following 5 minutes exposure.