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Diss Factsheets
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EC number: 219-348-1 | CAS number: 2421-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Valid scientific study, precedes guideline and GLP. Documentation is limited.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Principles of method if other than guideline:
- Test method is not described for this study, but a method is available for a concurrent study on a structural analogue (BTA) of this substance (BTDA) commissioned in the same laboratory. Therefore, it is likely that the method for the BTDA is identical to that of BTA, and therefore this method is described in the following record. Both studies precede the establishment of OECD methods and GLP.
- GLP compliance:
- no
- Remarks:
- precedes establishment of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- EC Number:
- 219-348-1
- EC Name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- Cas Number:
- 2421-28-5
- Molecular formula:
- C17H6O7
- IUPAC Name:
- 5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dione
- Reference substance name:
- 291-348-1
- IUPAC Name:
- 291-348-1
- Test material form:
- not specified
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: albino Mason Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Food was withheld from all animals for 3 to 4 hours prior to dosing. Food and water were available ad libitum throughout the observation period. The animals were housed separately suspended above the droppings for the 13 day period of observation.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% methyl cellulose
- Details on oral exposure:
- The test material was administered as a single dose by oral gavage. The substance was administered as a suspension in 1% methylcellulose (Methocel). The volumes administered to each respective group of rats varied in relation to the individual animal body weight and each respective dose level.
- Doses:
- 6 doses, ranging from 5000 to 14700 mg/kg body weight.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- The animals were observed for mortality and pharmacodynamic and/or toxic effects at the following intervals after compound administration: immediately; at 1, 4 and 24 hours; and once daily for 13 days thereafter. At the termination of the observation period, all surviving animals were weighed, sacrificed by decapitation and necropsied.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 12 800 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 11 400 - < 14 500
- Other findings:
- At doses of 10,000 mg/kg or higher, BTDA produced gastrointestinal irritation and hemorrhage.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute oral LD50 for 1,3-Isobenzofurandione, 5,5'-carbonylbis- (BTDA) is 12,800 mg/kg bw in male rats.
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