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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 234-521-1 | CAS number: 12007-89-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Case study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- other: Case study
- Rationale for reliability incl. deficiencies:
- other: Not applicable as this is a case study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Accidental boric acid poisoning following the ingestion of household pesticide.
- Author:
- Hamilton RA & Wolf BC
- Year:
- 2 007
- Bibliographic source:
- J. Forensic Sci. 52 (3) 706 – 8
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The reference describes a poisoning incident in humans.
- GLP compliance:
- no
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- H3BO3
- IUPAC Name:
- Boric acid
- Details on test material:
- - Name of test material: Boric acid-containing roach powder.
Constituent 1
Method
- Subjects:
- Number of subjects exposed: One
- Sex: Female
- Age: 18-months old
- Known diseases: The child had no documented past medical history. - Route of exposure:
- oral
- Reason of exposure:
- accidental
- Exposure assessment:
- measured
Results and discussion
- Clinical signs:
- The child was pronounced dead at the emergency room. No clinical signs were therefore described.
- Results of examinations:
- A post-mortem examination was performed 28 h after the child’s death. The stomach contained 80 cc of thick green-brown liquid and the small and large intestines focally contained a light brown, liquid material. Routine toxicological studies were negative. A heart-blood borate concentration of 8316 mcg/dL (reference range toxic > 2000 mcg/dL) and a gastric content borate concentration of 6048 mg/L.
Applicant's summary and conclusion
- Conclusions:
- The case of an 18-month-old child who died following the accidental ingestion of boric acid-containing commercially available roach pesticide product was described. A post-mortem examination was performed 28 h after the child’s death. The stomach contained 80 cc of thick green-brown liquid and the small and large intestines focally contained a light brown, liquid material. Routine toxicological studies were negative. A heart blood borate concentration of 8316 mcg/dL (reference range toxic > 2000 mcg/dL) and a gastric content borate concentration of 6048 mg/L. The cause of death was attributed to accidental acute borax toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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