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Diss Factsheets
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EC number: 205-016-3 | CAS number: 131-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 12, to February 6, 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- modification in the preparation of the aqueous media
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- yes
- Remarks:
- modification in the preparation of the aqueous media
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sample storage conditions before analysis: -20°C for further analysis
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: dissolution
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): reconstituted water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnid
- Strain: Daphnia magna
- Source: in-house laboratories
- Age at study initiation (mean and range, SD): less than 24 hr old
- Culture conditions: reproduction by parthenogenesis - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21°C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 8.8- 8.9 (>98% of air saturation value)
- Salinity:
- Freshwater, not specified.
- Nominal and measured concentrations:
- Nominal: 0.10, 0.18, 0.32, 0.56, 1.0, 1.8, 3.2, 5.6 & 10 mg/l
Measured test concentrations ranged from 92% to 108% of nominal. - Details on test conditions:
- TEST SYSTEM
- Test vessel: polypropylene vessels
- Type (delete if not applicable): closed
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 10
OTHER TEST CONDITIONS
- Photoperiod: 16 hr light/ 8 hr darkness with 20 min dawn and dusk transition periods
TEST CONCENTRATIONS
- Spacing factor for test concentrations: approx. 1.8
- Range finding study: yes
- Test concentrations: 0.10, 1.0, 10 & 100 mg/l
- Results used to determine the conditions for the definitive study: number of immobilised Daphnia - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Remarks on result:
- other: 95%CL: 4.8-6.4 mg/l
- Duration:
- 48 h
- Dose descriptor:
- other: EC0
- Effect conc.:
- 3.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- other: EC0
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Details on results:
- Results of the definitive test were inconsistent with those of the range-finding test. This has been evaluted in the report. In addition, the immobility recorded after 24h at 1.0 and 10 mg/l in the range-finding test indicated a rather flat concentration-response curve. The results of the definitive test were more convincing, showing a more clear concentration-response relationship.
- Results with reference substance (positive control):
- Instead of what is standard practise, no data were added on sensitivity of the daphnids by reporting the results of reference tests.
- Reported statistics and error estimates:
- EC50 calculation using the maximum likelihood probit analysis.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of diallyl phthalate to the freshwater invertebrate Daphnia magna expressed as the 48h-EC50 was 5.5 mg/l, with 95%-confidence limits of 4.8 - 6.4 mg/l and no effect at 3.2 mg/l (EC0). Measured concentrations were in agreement with nominal.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report of testing conducted in line with the provisional procedure proposed by the Federal Environmental Agency in Germany.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: German guideline (UBA)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Remarks on exposure duration:
- Pretest for a reproduction test
- Post exposure observation period:
- Not relevant
- Hardness:
- 2.5 mmol/L expressed as total calcium carbonate
- Test temperature:
- Not indicated
- pH:
- 8.0 +- 0.2
- Dissolved oxygen:
- Not indicated
- Salinity:
- Synthetic fresh water, salinity not specified.
- Nominal and measured concentrations:
- Not specified
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 26 mg/L
- Nominal / measured:
- nominal
- Remarks on result:
- other: Screening for reproduction test
- Results with reference substance (positive control):
- 24h-EC50=0.35 mg/l
- Reported statistics and error estimates:
- Not specified.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of diallyl phthalate to the freshwater invertebrate Daphnia magna expressed as the 24h-EC50 was 26 mg/l with the 24h-EC0 of 11 mg/l.
Referenceopen allclose all
Description of key information
Key information is based on a GLP study with Daphnia magna performed according to OECD guideline 202 in 2003. Analytical confirmation of test concentrations is included. Validity criteria concerning the control group and test conditions were met.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5.5 mg/L
Additional information
The acute toxicity of diallyl phthalate to the freshwater invertebrate Daphnia magna expressed as the 48h-EC50 was 5.5 mg/l, with 95%-confidence limits of 4.8 - 6.4 mg/l and no effect at 3.2 mg/l (NOEC). Measured concentrations were in agreement with nominal. The results for the 24h EC-values are supported by those of another study (Kühn et al., 1989).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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