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Diss Factsheets
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EC number: 270-674-0 | CAS number: 68476-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Near-guideline, GLP-compliant study. Adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The test substance was administered by oral gavage to male and female rats and animals observed for 14 days. Body weights were recorded the prior to treatment and again at gross necropsy on day 14.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 64741-62-4
- Cas Number:
- 64741-62-4
- IUPAC Name:
- 64741-62-4
- Test material form:
- other: Viscous hydrocarbon liquid
- Details on test material:
- Catalytic cracked clarified oil (CCCO), API 81-15, CAS No.
64741-62-4.
Tar like semi solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: approx. 9 wk
- Fasting period before study: overnight
IN-LIFE DATES: From: 3 March 1982 To: 17 March 1982
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals fasted prior to treatment
- Doses:
- 3.20, 4.00, 5.00, 6.25 and 7.81 g/kg body weight
- No. of animals per sex per dose:
- 5 per sex per dose level
- Control animals:
- no
- Details on study design:
- The test substance was administered by oral gavage to male and female rats and animals observed for 14 days. Body weights were recorded the prior to treatment and again at gross necropsy on day 14.
- Statistics:
- The LD50 was calculated according to the method of Finney (1971) Statistical Methods in Biological assay, 3rd edition, p50-90 (no further details)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 270 mg/kg bw
- 95% CL:
- 4 030 - 6 950
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 320 mg/kg bw
- 95% CL:
- 2 650 - 5 470
- Mortality:
- Mortality by dose level:
3200 mg/kg - 20%
4000 mg/kg - 40%
5000 mg/kg - 40%
6250 mg/kg - 80%
7810 mg/kg - 100% - Clinical signs:
- other: The main clinical signs were hypoactivity, ataxia, prostration, diarrhoea, hair loss and eye opacity
- Gross pathology:
- No abnormalities detected
- Other findings:
- None
Any other information on results incl. tables
In addition to mortalities, the main clinical signs were hypoactivity, ataxia, prostration, diarrhoea, hair loss and eye opacity. The LD50 values for male and female animals were 5270 and 4320 mg/kg respectively.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 = 4320 (females) - 5270 (males)
- Executive summary:
The test substance was administered to groups of fasted male and female SD rats (n = 5/sex) at dose levels of 3200 – 7810 mg/kg bw followed by a 14 day observation period.
Variable mortality was present at treatment levels of 4000 mg/kg bw and above, with complete mortality in the high dose group. The main clinical signs were hypoactivity, ataxia, prostration, diarrhoea, hair loss and eye opacity but no lesions were visible at scheduled necropsy in survivors.
The acute oral LD50 was 4320 mg/kg bw in females and 5270 mg/kg bw in males.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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