Registration Dossier
Registration Dossier
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EC number: 231-659-4 | CAS number: 7681-11-0
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: Summary of human data and estimation of TDI
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The published literature fulfilled basically scientific principles without GLP compliance statement
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 009
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 989
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 991
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 997
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Summary of human data and estimation of TDI
- GLP compliance:
- no
- Remarks:
- Summary of human data
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen iodide
- EC Number:
- 233-109-9
- EC Name:
- Hydrogen iodide
- Cas Number:
- 10034-85-2
- IUPAC Name:
- iodide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: human data
- Strain:
- other: human data
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- In the "details on oral exposure"
- Frequency of treatment:
- In the "details on oral exposure"
Doses / concentrations
- Remarks:
- Doses / Concentrations:
In the "details on oral exposure"
Basis:
no data
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 0.01 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- other: tolerable daily intake (TDI)
- Effect level:
- 0.01 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: A TDI of 0.01 mg/kg body weight, based upon reversible subclinical hypothyroidism, can be established by dividing the NOAEL of 0.01 mg/kg body weight per day by an uncertainty factor of 1.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- TDI of iodide is 0.01 mg/kg body weight.
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