Potassium bromide

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

The Influence of Dietary Chloride on Bromide Excretion in the Rat

Author:

Rauws A.G. and van Logten M.J.

Year:

1975

Bibliographic source:

Toxicology, 3 (1975) 29-32.

Materials and methods

Objective of study:

toxicokinetics

Test guideline

Qualifier:

no guideline available

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium bromide

EC Number:

231-599-9

EC Name:

Sodium bromide

Cas Number:

7647-15-6

IUPAC Name:

sodium bromide

Details on test material:

Potassium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to potassium bromide.

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Administration / exposure

Route of administration:

oral: feed

Vehicle:

other: Muracon SSP-Tox-Br

Duration and frequency of treatment / exposure:

21 day(s)
14 days post exposure observation

Doses / concentrations

Remarks:

Doses / Concentrations:
Females: 2000 ppm for all rats until plasma bromide levels were approximately 10 mmol/L

No. of animals per sex per dose / concentration:

Females: 30

Control animals:

yes

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters

Toxicokinetic parameters:

half-life 1st: 25 days

Metabolite characterisation studies

Metabolites identified:

no

Any other information on results incl. tables

Toxicological behaviour: In the rat, bromide half-life is prolonged from approximately 3 days to 25 days on a salt-free diet with tap water.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): no data
Five groups of female Wistar rats (6 rats per group) were all given feed containing 2000 ppm bromide daily ad libitum for 3 weeks. After this the five groups were placed on differing food and drinking water regimes with controlled chloride intake levels. The blood plasma bromide concentrations of all animals were measured 1, 2, 3, 4, 9 and 14 days after completion of the initial 3 weeks of bromide-supplemented feeding.
Chloride depletion prolongs the elimination half-life of bromide. In the rat, bromide half-life is prolonged from approximately 3 days to 25 days on a salt-free diet with tap water. The bromide half-life is shown to be approximately inversely proportional to the total chloride intake. If acceptable daily intakes are to be established, the influence of a salt-free diet on bromide half-life in man will have to be taken into account.