Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 480-290-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EG, B.26; OECD 408 (1998)
- GLP compliance:
- yes
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: diet
- Details on oral exposure:
- Method of administration:
oral - Duration of treatment / exposure:
- Test duration: 90 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 10 animals at 0 mg/kg bw/day
Male: 10 animals at 1.19 mg/kg bw/day
Male: 10 animals at 12.34 mg/kg bw/day
Male: 10 animals at 120.19 mg/kg bw/day
Male: 10 animals at 1203.8 mg/kg bw/day
Female: 10 animals at 0 mg/kg bw/day
Female: 10 animals at 1.63 mg/kg bw/day
Female: 10 animals at 16.08 mg/kg bw/day
Female: 10 animals at 162.49 mg/kg bw/day
Female: 10 animals at 1436.3 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
No animal died prescheduled.
No clinical signs attributable to the test substance were
noted up to 15000 ppm at clinical examinations including
open field observations.
The functional observations revealed no findings pointing
to a neurotoxic potential.
Data of MA and LMA did not reveal any findings attributable
to the treatment with the test substance.
There was no statistically significant body weight
reduction in males up to 15000 ppm. Females receiving
15 ppm exhibited a body weight development comparable with
that of controls. In the groups 150 and 1500 ppm the
terminal body weights of females were each about 8 % lower
than that at 0 ppm.
The ophthalmoscopy done near the terminal sacrifice revealed
no evidence of treatment-related effects.
Laboratory findings:
Hematological investigations revealed no toxic effect on
red and white blood or blood coagulation parameters.
Clinical laboratory tests reveales no indicaiton of toxic
effects on enzyme activities as well as substrate and
electrolyte concentrations in plasma.
No changes were noted in urine parameters.
There was an increase in number and severity score of
splenic hematopoietic activity in 15000 ppm females.
Effects in organs:
Gross and histopathological investigations into other
organs and tissues as well as organ weight measurements
gave no indications of test substance-related functional
or morphological changes in both sexes.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 1 203.8 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
- Dose descriptor:
- NOEL
- Effect level:
- 162.49 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.