Neodecanoic acid, cobalt salt

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-09-28 to 2009-12-02

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

2008-04-30

Type of method:

flask method

Water solubility:

772 mg/L

Temp.:

20 °C

pH:

>= 6.57 - <= 6.95

Remarks on result:

other: Based on a determined concentration of 113.36 mg Co/L

Water solubility:

2 872 mg/L

Temp.:

37 °C

pH:

>= 7.04 - <= 7.41

Remarks on result:

other: Based on a determined concentration of 421.87 mg Co/L

Details on results:

After shaking times of 72, 96 and 120 hours at 30 °C and at 47 °C, respectively, the samples were equilibrated for another 24 hours at 20 °C and 37 °C, respectively. Afterwards, the samples were centrifuged, diluted and analyzed by AAS. The water solubility of Cobalt Neodecanoate at 20 °C was determined to be 772 mg/L and at 37 °C 2872 mg/L. The measured results at 96 hours and 120 hours differ by less than 15%. Therefore, the study is considered to be valid

Sample No.	Shaking Time [h] at 30°C/47°C	Concentration Analyzed [mg Co/L]	Concentration Calculated [mg Co/L]	Concentration Calculated [mg test item/L]	Water Solubility Calculated (Rounded) [mg test item/L]
Test at 20 °C
1	120	4.387	109.68	746.60	772
2		4.990	124.75	849.22
3		4.607	115.18	784.04
4	96	5.132	128.30	873.38
5		3.939	98.48	670.35
6		4.058	101.45	690.61
7	72	4.192	104.80	713.41
8		4.969	124.23	845.64
9		8.425	210.63	1433.80*
Mean			113.36	771.66
SD			11.49	78.23
SD rel.			10.14%	10.14%
Test at 37 °C
1	120	10.640	532.00	3621.51*	2872
2		8.623	431.15	2934.99
3		9.526	476.30	3242.34
4	96	8.004	400.20	2724.30
5		7.865	393.25	2676.99
6		6.722	336.10	2287.95*
7	72	5.857	292.85	1993.53*
8		8.061	403.05	2743.70
9		8.545	427.25	2908.44
Mean			421.87	2871.79
SD			30.73	209.17
SD rel.			7.28%	7.28%

*outlier, not used for further calculations

SD = Standard Deviation

SD rel. = Relative Standard Deviation

The water solubility of the test item was calculated with a cobalt content of 14.69% as given by the Sponsor.

Conclusions:

Interpretation of results: moderately soluble (100-1000 mg/L) at 20°C and soluble (1000-10000mg/L) at 37°C.
According to OECD Guideline for Testing of Chemicals, No. 105, “Water solubility”; adopted July 27, 1995 and Council Regulation (EC) No. 440/2008, 30 May 2008, Part A, Methods for the determination of physico-chemical properties, A.6 “Water solubility” the water solubility of the test item at 20 °C and at 37 °C was determined using the flask method and was found to be 772 mg/L at 20 °C (based on a determined concentration of 113.36 mg Co/L) and 2872 mg/L at 37 °C (based on a determined concentration of 421.87 mg Co/L).

Description of key information

The water solubility of the test item is determined to be 772 mg/L at 20 °C and 2872 mg/L at 37 °C.

Key value for chemical safety assessment

Water solubility:

772 mg/L

at the temperature of:

20 °C

Additional information

According to OECD Guideline for Testing of Chemicals, No. 105, “Water solubility”; adopted July 27, 1995 and Council Regulation (EC) No. 440/2008, 30 May 2008, Part A, Methods for the determination of physico-chemical properties, A.6 “Water solubility” the water solubility of the test item at 20 °C and at 37 °C was determined using the flask method and was found to be 772 mg/L at 20 °C (based on a determined concentration of 113.36 mg Co/L) and 2872 mg/L at 37 °C (based on a determined concentration of 421.87 mg Co/L).