Registration Dossier
Registration Dossier
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EC number: 200-471-4 | CAS number: 60-34-4
Other distribution data
Administrative data
- Endpoint:
- other distribution data
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- not applicable (QSAR)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- QSAR estimate by an internationally recognized QSAR, within its applicability domain, with correct recognition of the chemical family (hydrazines) and of the compound structure, and based on several experimental data (boiling point, melting point, vapour pressure) which were correctly re-estimated by this QSAR.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- EPI Suite Results For CAS 000060-34-4
- Author:
- Anonymous
- Year:
- 2 010
- Bibliographic source:
- US EPA's Office of Pollution Prevention and Toxics + Syracuse Research Corporation, Estimation Programs Interface (EPI) Suite, v4.00
Materials and methods
- Principles of method if other than guideline:
- QSAR estimation by KOAWIN v1.10, based on following:
- identification data: SMILES= N(N)C, CAS= 000060-34-4 (software recognizes structure, name and ECOSAR Class= hydrazines)
- experimental input: boiling point, melting point, vapour pressure: values as in IUCLID
- the estimation method used the HENRYWIN v3.20 estimate of Henry's law constant - GLP compliance:
- no
- Remarks:
- QSAR
- Type of study:
- volatility
- Media:
- other: octanol-air
Test material
- Reference substance name:
- Methylhydrazine
- EC Number:
- 200-471-4
- EC Name:
- Methylhydrazine
- Cas Number:
- 60-34-4
- Molecular formula:
- CH6N2
- IUPAC Name:
- methylhydrazine
Constituent 1
Results and discussion
Any other information on results incl. tables
Log Octanol-Air Partition Coefficient (25 deg C): Log Koa = 4.839
Applicant's summary and conclusion
- Executive summary:
The Octanol-Air Partition Coefficient estimated by QSAR by KOAWIN v1.10 inside EPIsuite v4.00, is Log Koa = 4.839. The substance partitions more to lipid phase than to air (due to low volatility).
The relevance of the estimate is confirmed by the coherence of three other estimates with available experimental data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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