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Diss Factsheets
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EC number: 219-844-8 | CAS number: 2550-06-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002/05/07-2002/06/14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Trichloro(3-chloropropyl)silane
- EC Number:
- 219-844-8
- EC Name:
- Trichloro(3-chloropropyl)silane
- Cas Number:
- 2550-06-3
- Molecular formula:
- C3H6Cl4Si
- IUPAC Name:
- trichloro(3-chloropropyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD/Crl:CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, Sandhofer Weg 7, D-97633 Sulzfeld
- Age at study initiation: 41 days, females; 48 days, males
- Weight at study initiation: 167-192g females, 189-203g males
- Fasting period before study: 16 hours
- Housing: cages
- Diet: ssniff R/M-HV 1530 ad libitum, feeding was discontinued ca. 16 hours before administration
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 55 ± 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: corn oil for the 200 mg/kg dose
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.48 ml/kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The dose is selected from a series of defined dose levels. The substance is tested using a stepwise procedure, each step uses three animals of one sex. Three animals of one sex are treated at 2000 mg/kg bw. When two or three animals die, testing at 200 mg/kg bw is performed. When fewer than two animals die, the substance should be retested with 2000 mg/kg bw using three animals of the other test. If two or three animals die, testing at 200 mg/kg bw should be performed. When in this second step, fewer than two animals die, no further testing is necessary.
When the results of the test at 2000 mg/kg bw indicate need for further testing at a lower dose level. Three animals of sex 1 are treated 200 mg/kg bw. When two or three animals die, testing at 25 mg/kg bw should be performed. When fewer than two animals die, the substance should be retested with 200 mg/kg bw, using three animals of the other sex. If in this second step, two or three animals die, testing at 25 mg/kg bw should be performed. When in this second step, fewer than 2 animals die, no further testing is necessary. - Doses:
- 200 and 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 6M, 3F
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed before and immediately at 5, 15, 30 and 60 minutes, as well as at 3,6 and 24 hours after administration. Body weights were recorded before adminstration of test substance and thereafter in weekly intervals up to the end of the study, and at death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: During the 14 day observation period, changes of skin and fur, eyes and mucous membranes, respiratory and circulatory, autonomic and central nervous system, somatomotor activity as well as behaviour pattern were observed at least once a day until symptoms subsided, thereafter each working day. Attention was also paid to possible tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma. All gross pathological changes were recorded after termination, a microscopic examination of all organs which showed evident lesions was performed. - Statistics:
- No statistical analysis was performed (the method used was not intended to allow the calculation of a precise LD50 value).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 2 000 mg/kg bw
- Mortality:
- 2000 mg/kg bw resulted in death within 5 min of all male animals. None of the six rats employed at 200 mg/kg bw died.
- Clinical signs:
- 2000 mg/kg bw resulted following signs of systemic toxicity; reduced motility, ataxia, reduced muscle tone, dyspnoea. All animals at 200 mg/kg bw showed signs of systemic toxicity.
- Body weight:
- 2/3 surviving female animals gained the expected body weight within the study period, one of 3 female animals showed a body weight reduction of 12.5%. All male surviving animals gained the expected body weight within the study period.
- Gross pathology:
- No abnormalities were found at microscopic post mortem examination of the animals.
- Other findings:
- None reported.
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
||
Male |
Female |
Combined |
||
200 |
0/3 |
0/3 |
0/6 |
|
2000 |
3/3 |
|
3/3 |
6 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value within the range of 200 to 2000 mg/kg was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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