Registration Dossier
Registration Dossier
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EC number: 234-390-0 | CAS number: 11138-47-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The database concerning absorption, distribution, metabolism and excretion for sodium perborate is very limited.
As stated in the EU RAR, the oral absorption is > 30% (data from a study with human volunteers). There are no valid quantitative data on the absorption of sodium perborate following dermal exposure. Absorption from the mucous membranes of the mouth seems to be low. Dermal absorption of H2O2 is negligible and a thorough investigation showed that the dermal absorption of other boron compounds is very low.
Peak levels in human plasma presumably after swallowing of sodium perborate are reached after 2 hours (t1/2 in plasma is about 6 to 10 hours). After oral uptake sodium perborate is assumed to be degraded to boric acid and H2O2 and to be excreted as boric acid via the urine. There are no data concerning distribution of sodium perborate (and subsequent degradation products) within the body. From investigations with other boron compounds, it may be suspected that elevated boron concentrations are found in the bones.
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