Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-652-8 | CAS number: 67-43-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well conducted and reported study according to GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 412
- Deviations:
- yes
- Remarks:
- exposure until day 5 only
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: subacute
- Limit test:
- yes
Test material
- Reference substance name:
- Disodium dihydrogen ethylenediaminetetraacetate
- EC Number:
- 205-358-3
- EC Name:
- Disodium dihydrogen ethylenediaminetetraacetate
- Cas Number:
- 139-33-3
- IUPAC Name:
- disodium dihydrogen 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
- Details on test material:
- Purity 91.7%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- clean air
- Details on inhalation exposure:
- A dust aerosol was generated
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetry
- Duration of exposure:
- 6 h
- Remarks on duration:
- per day 5 consecutive days
- Concentrations:
- 0, 30, 300 and 1000 mg/m3
- No. of animals per sex per dose:
- 10 per group main study
10 per group (control and high concentration; recovery groups) - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: LC30
- Effect level:
- 1 000 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- 6 out of 20 animals of the high concentration group died after the first exposure or the day after. The others of this group were kept for 14 days (as if it were an acute inhalation study).
- Clinical signs:
- other: Several respiratory tract changes
- Body weight:
- Decreased
- Gross pathology:
- Congestion, oedema and multifocal haemorrhages in animals of the high concentration group
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Based on a 6-h LC30 value (30% mortality folowing a 6-h exposure), it may be assumed that the 4-h LC50 value will be between 1000 and 5000 mg/m3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
