(1R,4S,4aR,8aS)-9-(dichloromethylidene)octahydro-1,4-methanonaphthalene-5,8-dione

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2011-02-04 to 2011-02-15 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to a relevant guideline without deviations. It was not carried out according to GLP, but it was performed in a test facility which has been certified to be in compliance with the principles of GLP.

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

from May 30, 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Version / remarks:

adopted July 27, 1995

Deviations:

no

GLP compliance:

no

Remarks:

However, the study was performed in a test facility which has been certified to be in compliance with the principles of GLP.

Type of method:

differential scanning calorimetry

Remarks:

Thermal analysis in combination with capillary test

Atm. press.:

98 kPa

Decomposition:

yes

Decomp. temp.:

260 °C

Remarks on result:

other: The test item decomposes before boiling occurs.

Preliminary test

An endothermic heat effect (melting) was observed at 177.8 °C. At 314.3 °C a broad endothermic peak was observed. After the experiment, the sample had lost about 61% of its mass and a black carbonized foamed residue remained.

Main Tests

A differential scanning calorimetry main test run was recorded between 25 °C and 400 °C with a heating rate of 10 °C/min. A first clear endothermic reaction was observed at 173.9 °C followed by a broad endothermic reaction starting at about 263.7 °C.

A capillary test was performed in the temperature range between 200 °C and 350 °C (heating rate 10 °C/min) for further clarification. At 220 °C the test item emitted one big air bubble every 15 sec. At 252.3 °C and 257.6 °C, respectively, fine bubbles were observed in both capillaries. At 260 °C the test item turned black indicating the decomposition of the test item. At 280 °C

boiling was observed.

Conclusions:

The test item decomposes before boiling occurs starting at about 260 °C at an atmospheric pressure of 98.0 kPa. The study is considered to be adequate and reliable.

Executive summary:

The determination of the boiling point / boiling range of the test item was performed according to OECD Guideline No. 103: "Boiling point", adopted July 27, 1995.

In a preliminary differential scanning calorimetry test which was performed as part of a study to determine the melting point, an endothermic heat effect (melting) was observed at 177.8 °C. At 314.3 °C, a broad endothermic peak was observed. A differential scanning calorimetry main test run was recorded between 25 °C and 400 °C with a heating rate of 10 °C/min. A first clear endothermic reaction was observed at 173.9 °C followed by a broad endothermic reaction starting at about 263.7 °C. A capillary test was performed in the temperature range between 200 °C and 350 °C (heating rate 10 °C/min) for further clarification. At 220 °C the test item emitted one big air bubble every 15 sec. At 252.3 °C and 257.6 °C, respectively, fine bubbles were observed in both capillaries. At 260 °C the test item turned black indicating the decomposition of the test item. At 280 °C, boiling was observed.

In conclusion, the test item decomposes before boiling occurs starting at about 260 °C at an atmospheric pressure of 98.0 kPa.

Description of key information

Decomposes before boiling at about 260 °C at 98.0 kPa, OECD 103, DSC; thermal analysis, Kühne 2011

Additional information

Only a single study conducted according to guidelines is available for this endpoint. The study is considered to be relevant, reliable (Klimisch 1) and adequate for the purposes of risk assessment, classification and labelling.