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Diss Factsheets
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EC number: 203-696-6 | CAS number: 109-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
oral: LD50 > 2000 < 5000 mg/kg bw (WoE: Rudnev et al. 1979, rat and mouse, Smyth et al. 1954, rat)
inhalation: LC 50 (rat) > 7.74 mg/L air (90-0524-FGT)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 1st- 31th, 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- , 1981
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Lippische Versuchstierzucht HAGEMANN GmbH & Co., Exertal 1, Germany
- Age at study initiation: 51 - 54 days
- Weight at study initiation: 229 - 249 g (males); 212 - 250 g (females)
- Fasting period before study: 16 hours
- Housing: in groups of two or three in MAKROLON cages (type III)
- Diet: ad libitum standardized diet for rats ALTROMIN 1324 (ALTROMIN GmbH, Lage/Lippe, Germany); analysed for contaminants
- Water: ad libitum tap water; analysed regularly
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/-2
- Humidity (%): 50 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: Feb. 1990 To: March 15th, 1990 - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic inhalation apparatus with a nose-only exposure according to Kimmerle & Trepper.
- Exposure chamber volume: 40 L
- Method of holding animals in test chamber: Apparatus consists of a cylindrical exposure chamber which holds a maximum of 20 animals in pyrex tubes at the edge of the chamber in a radial position
- Source and rate of air: 400 L/h
- System of generating particulates/aerosols: A mixture of test substance and air was obtained using a spray-jet. The spray-jet was fed with compressed air from a compressor and with the test article using an infusion pump and a 50 mL syringe.
- Temperature, humidity, pressure in air chamber: 22 +/- 3°C
TEST ATMOSPHERE
- Brief description of analytical method used: GC-analyses of two air samples
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: Test substance is of volatile nature at room temperture (vapour pressure 10700 Pa at 20°C). This resulted in an almost complete gas phase in the inhalation chamber after the test substance air mixture escaped from the spray-jet. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 1.49 and 7.74 mg/L air (actual concentrations)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Observations and clinical examiniations: on the day of exposure 5, 15, 30 and 60 min, 3 h and 24 h after end of exposure; during recovery period at least once a day until all symptoms had subsided, thereafter each working day.
Individual body weight: before the exposure and after exposure in weekly intervals; if animals died body weight at time-point of death was recorded.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight gain - Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7.74 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occured.
- Clinical signs:
- other: No substance-related intolerance reactions were observed.
- Body weight:
- No inhibition of body weight gain was examined.
- Gross pathology:
- Macroscopic inspection revealed no pathological findings.
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral:
In acute oral toxicity tests Rudnev et al. (1979) exposed albino rats and white mice to 1-chlorobutane. LD50s of 2200 mg/kg bw and 5600 mg/kg bw were examined, respectively, indicating that rats may be more sensitive to 1-chlorobutane than mice. No further information on mortality, clinical signs or necropsy were provided. In another acute oral toxicity test 5 female rats were intubated with a logarithmic series of doses (Smyth et al., 1954). 14 days after dosing, mortality was considered to be complete (LD50: 2670 mg/kg bw).
Taken together in a weight of evidence approach, the data indicate that the test material has a low toxic potential to rats and mice after oral ingestion.
Inhalation:
In a GLP-guideline study according to OECD 403 (1981) rats were exposed to 1-chlorobutane via aerosol inhalation to actual concentrations of 1.49 and 7.74 mg/L air over an exposure period of 4 hours (90-0524-FGT). No substance-related toxicity was observed and no mortality occurred. Macroscopic inspection revealed no pathological findings. Thus the LC50 was determined to be > 7.74 mg/L air. An inhalative LC50 value for male rats was reported as > 8000 ppm (> 30 mg/L) after an exposure period of 4 hours to the vapour of 1-chlorobutane by Smyth et al.(1954). Two of six male rats died within an observation period of 14 days after exposure.
Dermal:
In an acute dermal toxicity study with rabbits, available as short abstract only, no effects were detected after 24 hours of exposure to very high amounts of 1-chlorobutane (LD50 > 20 ml/kg).The test substance was applied occlusively to 1/10 of the body surface (Smyth et al., 1954).
Justification for selection of acute toxicity – oral endpoint
Weight of evidence approach.
Justification for classification or non-classification
The available data is conclusive but not sufficient for classification according to DSD (67/548/EEC) and CLP (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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