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Diss Factsheets
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EC number: 287-479-1 | CAS number: 85535-87-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1977-12-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restriction because although it is an acceptable and well documented study report a GLP statement was not provided and details regarding the test material and animal husbandry was not provided.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: not provided
- Principles of method if other than guideline:
- The internal olefin 114 LP11 was administered by intraoesophageal intubation using a ballpoint needle fitted to a syringe.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Alkenes, C11-15
- IUPAC Name:
- Alkenes, C11-15
- Details on test material:
- - Name of test material (as cited in study report): Internal olefin 114 LP11
- Test substance: Alkenes, C11-15
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Shell Toxicology Laboratory (Tunstall), Breeding Unit
- Age at study initiation: Approximately 12 weeks old
- Weight at study initiation: Not reported
- Fasting period before study: Overnight
- Housing: Four animals of one sex were housed in each cage.
- Diet (e.g. ad libitum): d libitum after dosing.
- Water (e.g. ad libitum): Ad libitum after dosing
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Administration / exposure
- Route of administration:
- other: intraoesophageal intubation
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE - Substance was undiluted
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
DOSAGE PREPARATION (if unusual): No data
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data - Doses:
- 5.0 mL/kg and 10 mL/kg
- No. of animals per sex per dose:
- Four male and four female per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 9 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: No data - Statistics:
- No data
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 10 mL/kg bw
- Remarks on result:
- other: 10 mL/kg is equivalent to 7600 mg/kg
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- 10 mL/kg bw
- Remarks on result:
- other: 10 mL/kg is equivalent to 7600 mg/kg
- Mortality:
- No animals died at the 5.0 mL/kg dose level. Two male rats died at the 10 ml/kg dose level, no female rats died at this dose level.
- Clinical signs:
- other: Animals that died did not eat or drink during the observation period. No clinical signs were reported for surviving animals.
- Gross pathology:
- No data
- Other findings:
- - Organ weights: No data
- Histopathology: No data
- Potential target organs: No data
- Other observations: No data
Applicant's summary and conclusion
- Conclusions:
- No animals died at the 5.0 mL/kg dose level. Two male rats died at the 10 mL/kg dose level, no female rats died at this dose level. The estimated LD50 was calculated to be > 10 mL/kg (i.e., >7600 mg/kg) for females and 10 mg/kg (i.e., 7600 mg/kg) for male rats.
- Executive summary:
In an acute oral toxicity study, two groups of four male and four female, fasted, approximately 12 week old, Wistar rats were given a single oral dose of Internal olefin 114 LP11 at doses of 5.0 and 10 mL/kg and observed for 9 days.
No animals died at the 5.0 mL/kg dose level. Two male rats died at the 10 mL/kg dose level, no female rats died at this dose level. There were no treatment related clinical signs, necropsy data was provided. Animals who did not survive were reported to not eat or drink during the observation period, thus loosing weight. The oral LD50 was estimated to be approximately > 10 mL/kg in females (i.e., >7600 mg/kg) and 10 mL/kg (7600 mg/kg) in males.
This study received a Klimisch score of 2 and is classified as reliable with restriction because although it is an acceptable and well documented study report a GLP statement was not provided and details regarding the test material and animal husbandry was not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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